Synthesis and Pharmacological Evaluation of 4-Aryloxyquinazoline Derivatives as Potential Cytotoxic Agents

被引：3
作者：
Malhotra, Anjleena [1 ]
Kaur, Tejinder [1 ]
Bansal, Ranju [1 ]
机构：
[1] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2019年 / 56卷 / 10期
关键词：
QUINAZOLINE; CANCER; INHIBITION; CHALCONES; DESIGN; GROWTH; UREAS;
D O I：
10.1002/jhet.3683
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the present study, novel 4-aryloxyquinazoline derivatives were synthesized and screened for in vitro cytotoxicity on human cancer cell lines at 10 mu M. Some of the synthesized compounds displayed moderate to significant and selective cytotoxic activity against various leukemia, melanoma, ovarian, breast, and colon cancer cell lines. (E)-3-(3,4-Dimethoxyphenyl)-1-(4-(quinazolin-4-yloxy)phenyl)prop-2-en-1-one (9b) was the most potent compound among all with an average growth inhibition of 70% against leukemia cancer cell lines. The compound also produced strong inhibition (75%) of colon cancer cell lines with 42.58% lethality of HCT-116 cell line.
引用
收藏
页码：2902 / 2911
页数：10
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