Synthesis, characterization, and cytotoxic properties of platinum(II)-amine complexes.: X-ray crystal structure determination of [Pt(C6H12N4) Cl2] • 3H2O

被引：7

作者：

Cheng, Kui

Zhu, Hai-Liang ^{[1
]}

Li, Zhi-Bin

机构：

[1] Wuhan Univ Sci & Engn, Dept Chem, Wuhan 430073, Peoples R China

[2] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Inst Funct Biomol, Nanjing 210008, Peoples R China

来源：

SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY | 2006年 / 36卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Pt(II) complexes; crystal structure; anti-tumour activity; cytotoxicity;

D O I：

10.1080/15533170601028181

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Three platinum(II) complexes of amines(L) have been prepared and structurally characterized and activity determined, where L is triethylenediamine, hexamethylenetetramine or pyridine, respectively. Crystal structure of [Pt(C6H12N4)Cl-2] center dot 3H(2)O was determined by X-ray single analysis, indicating that it is a ciscompound, and with the space group of C2/c, monoclinic, and a = 27.540(2) angstrom, b = 9.175(5) angstrom, c = 9.996(3) angstrom, beta = 104.37(3)degrees, U = 2447.1(2) angstrom(3), Z = 8, Dx = 2.466 g cm(-3). The result of antitumor activity assay indicated that these complexes inhibited the growth of several human solid carcinoma cell lines strongly.

引用

页码：719 / 722

页数：4

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