Pregnancy and breastfeeding: a new theory for sHLA-G in breast cancer patients?

被引：4

作者：

Zidi, Ines ^{[1
]}

Kharrat, Najla ^{[2
]}

Sebai, Refaat ^{[3
]}

Zidi, Nour ^{[3
]}

Ben Yahia, Hamza ^{[1
]}

Bouaziz, Aicha ^{[4
]}

Rifi, Hela ^{[3
]}

Mezlini, Amel ^{[3
]}

Rizzo, Roberta ^{[5
]}

机构：

[1] Univ Tunis El Manar, Fac Sci Tunis, Dept Biol, Lab Microorganismes & Act Biomol, Tunis 2092, Tunisia

[2] Ctr Biotechnol Sfax, Lab Mol & Cellular Screening Proc, Route Sidi Mansour,BP1177, Sfax 3018, Tunisia

[3] Salah Azaiz Inst, Dept Med Oncol, Tunis, Tunisia

[4] Ecole Super Sci & Tech Sante Sousse, Tunis, Tunisia

[5] Univ Ferrara, Dept Expt & Diagnost Med, Microbiol Sect, I-44100 Ferrara, Italy

来源：

IMMUNOLOGIC RESEARCH | 2016年 / 64卷 / 02期

关键词：

sHLA-G; Breast cancer; Pregnancy; Breastfeeding; HLA-G GENE; PLASMA; EXPRESSION; POLYMORPHISMS; PREECLAMPSIA; MOLECULE; TUMORS; CELLS; SERUM;

D O I：

10.1007/s12026-015-8764-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is now widely recognized that HLA-G molecule is implicated in immune tolerance and particularly in immune subversion of tumor cells. In this study, we explored levels of soluble HLA-G (sHLA-G) in plasma samples obtained from women with breast cancer (BC). Additionally, we correlated sHLA-G concentration with pregnancy and breastfeeding history. We reported in this preliminary work significant differences in sHLA-G levels between BC patients with/without breastfeeding experience (p = 0.04). Interestingly, among women with BC, only those without previous pregnancy experience present significant increase in sHLA-G (p = 0.02). Of relevance, we demonstrated that patients without both pregnancy and breastfeeding history have advanced SBR III grade, associated with significant enhancement in tumor size compared with patients who had both experiences (p = 0.028). Taken together, our results indicate the potential implication of previous pregnancy and breastfeeding experience in sHLA-G expression during BC. We theorized that having pregnancy and breastfeeding history may protect against advanced BC stages.

引用

页码：636 / 639

页数：4