Direction specific release from giant microgel-templated polyelectrolyte microcontainers

被引:48
作者
Bedard, Matthieu F. [2 ,3 ]
De Geest, Bruno G. [1 ]
Moehwald, Helmuth [2 ]
Sukhorukov, Gleb B. [3 ]
Skirtach, Andre G. [2 ]
机构
[1] Univ Ghent, Dept Pharmaceut, B-9000 Ghent, Belgium
[2] Max Planck Inst Colloids & Surfaces, Potsdam, Germany
[3] Queen Mary Univ London, Dept Mat, London, England
关键词
MULTILAYER FILM MORPHOLOGY; ENCAPSULATED MATERIALS; METAL NANOPARTICLES; SWELLING PRESSURE; MICROCAPSULES; HYDROGELS; AGGREGATION; DEGRADATION; ABSORPTION; CAPSULES;
D O I
10.1039/b909919k
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Giant polyelectrolyte microcapsules constructed on dex-HEMA microgel as a sacrificial template and functionalized with gold nanoparticles were found to have the ability to release encapsulated material in a pre-determined direction by selectively irradiating a given region of a capsule's wall with an infrared laser. This technology is envisioned to provide other applications in bio-medicine, an analogue of gene-gun technology on the micro-level for transfecting cells.
引用
收藏
页码:3927 / 3931
页数:5
相关论文
共 31 条
  • [1] Light-responsive polyelectrolyte/gold nanoparticle microcapsules
    Angelatos, AS
    Radt, B
    Caruso, F
    [J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2005, 109 (07) : 3071 - 3076
  • [2] Toward self-assembly of nanoparticles on polymeric microshells:: Near-IR release and permeability
    Bedard, Matthieu F.
    Braun, Dieter
    Sukhorukov, Gleb B.
    Skirtach, Andre G.
    [J]. ACS NANO, 2008, 2 (09) : 1807 - 1816
  • [3] Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating
    Caruso, F
    Caruso, RA
    Möhwald, H
    [J]. SCIENCE, 1998, 282 (5391) : 1111 - 1114
  • [4] Intracellularly degradable polyelectrolyte microcapsules
    De Geest, BG
    Vandenbroucke, RE
    Guenther, AM
    Sukhorukov, GB
    Hennink, WE
    Sanders, NN
    Demeester, J
    De Smedt, SC
    [J]. ADVANCED MATERIALS, 2006, 18 (08) : 1005 - +
  • [5] Microcapsules Ejecting Nanosized Species into the Environment
    De Geest, Bruno G.
    McShane, Michael J.
    Demeester, Jo
    De Smedt, Stefaan C.
    Hennink, Wim E.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (44) : 14480 - +
  • [6] Self-Exploding Beads Releasing Microcarriers
    De Geest, Bruno G.
    De Koker, Stefaan
    Immesoete, Kristof
    Demeester, Jo
    De Smedt, Stefaan C.
    Hennink, Wim E.
    [J]. ADVANCED MATERIALS, 2008, 20 (19) : 3687 - +
  • [7] De Geest BG, 2007, CHEM SOC REV, V36, P636, DOI 10.1039/b600460c
  • [8] Polyelectrolyte microcapsules for biomedical applications
    De Geest, Bruno G.
    De Koker, Stefaan
    Sukhorukov, Gleb B.
    Kreft, Oliver
    Parak, Wolfgang J.
    Skirtach, Andrei G.
    Demeester, Jo
    De Smedt, Stefaan C.
    Hennink, Wim E.
    [J]. SOFT MATTER, 2009, 5 (02) : 282 - 291
  • [9] Pulsed in vitro release and in vivo behavior of exploding microcapsules
    De Geest, Bruno G.
    De Koker, Stefaan
    Demeester, Jo
    De Smedt, Stefaan C.
    Hennink, Wirn E.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2009, 135 (03) : 268 - 273
  • [10] In vivo cellular uptake, degradation, and biocompatibility of polyelectrolyte microcapsules
    De Koker, Stefaan
    De Geest, Bruno G.
    Cuvelier, Claude
    Ferdinande, Liesbeth
    Deckers, Wies
    Hennink, Wim E.
    De Smedt, Stefaan
    Mertens, Nico
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2007, 17 (18) : 3754 - 3763