ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

被引：136
作者：
Casini, Angela
Mastrobuoni, Guido
Temperini, Claudia
Gabbiani, Chiara
Francese, Simona
Moneti, Gloriano
Supuran, Claudiu T.
Scozzafava, Andrea
Messori, Luigi
机构：
[1] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, Italy
[2] Univ Florence, Mass Spectrometry Ctr, I-50019 Sesto Fiorentino, Italy
来源：
CHEMICAL COMMUNICATIONS | 2007年 / 02期
关键词：
D O I：
10.1039/b611122j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 angstrom resolution, reveals selective platination of imidazole N epsilon of His15.
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收藏
页码：156 / 158
页数：3
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