A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis

被引:87
作者
Tanne, Antoine [1 ,2 ,5 ]
Ma, Bo [3 ]
Boudou, Frederic [2 ]
Tailleux, Ludovic [2 ]
Botella, Helene [1 ,5 ]
Badell, Edgar [2 ]
Levillain, Florence [1 ,5 ]
Taylor, Maureen E. [4 ]
Drickamer, Kurt [4 ]
Nigou, Jerome [1 ,5 ]
Dobos, Karen M. [6 ]
Puzo, Germain [1 ,5 ]
Vestweber, Dietmar [7 ]
Wild, Martin K. [7 ]
Marcinko, Marie [3 ]
Sobieszczuk, Peter [3 ]
Stewart, Lauren [3 ]
Lebus, Daniel [3 ]
Gicquel, Brigitte [2 ]
Neyrolles, Olivier [1 ,2 ,5 ]
机构
[1] Univ Toulouse 3, Univ Toulouse, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France
[2] Inst Pasteur, Mycobacterial Genet Unit, F-75724 Paris, France
[3] Scripps Res Inst, Dept Physiol Chem, Consortium Funct Glyc, La Jolla, CA 92037 USA
[4] Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England
[5] Univ Toulouse 3, Univ Toulouse, CNRS, F-31077 Toulouse, France
[6] Colorado State Univ, Dept Microbiol Immunol & Pathol, Mycobacteria Res Labs, Ft Collins, CO 80523 USA
[7] Max Planck Inst Mol Biomed, D-48149 Munster, Germany
基金
英国惠康基金;
关键词
C-TYPE LECTINS; TOLL-LIKE RECEPTORS; DENDRITIC CELL; IMMUNE-RESPONSE; MICE LACKING; MOUSE DC; RECOGNITION; INFECTION; DECTIN-1; MACROPHAGES;
D O I
10.1084/jem.20090188
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The C-type lectin dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) mediates the innate immune recognition of microbial carbohydrates. We investigated the function of this molecule in the host response to pathogens in vivo, by generating mouse lines lacking the DC-SIGN homologues SIGNR1, SIGNR3, and SIGNR5. Resistance to Mycobacterium tuberculosis was impaired only in SIGNR3-deficient animals. SIGNR3 was expressed in lung phagocytes during infection, and interacted with M. tuber-culosis bacilli and mycobacterial surface glycoconjugates to induce secretion of critical host defense inflammatory cytokines, including tumor necrosis factor (TNF). SIGNR3 signaling was dependent on an intracellular tyrosine-based motif and the tyrosine kinase Syk. Thus, the mouse DC-SIGN homologue SIGNR3 makes a unique contribution to protection of the host against a pulmonary bacterial pathogen.
引用
收藏
页码:2205 / 2220
页数:16
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