A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis

被引：87

作者：

Tanne, Antoine ^{[1
,2
,5
]}

Ma, Bo ^{[3
]}

Boudou, Frederic ^{[2
]}

Tailleux, Ludovic ^{[2
]}

Botella, Helene ^{[1
,5
]}

Badell, Edgar ^{[2
]}

Levillain, Florence ^{[1
,5
]}

Taylor, Maureen E. ^{[4
]}

Drickamer, Kurt ^{[4
]}

Nigou, Jerome ^{[1
,5
]}

Dobos, Karen M. ^{[6
]}

Puzo, Germain ^{[1
,5
]}

Vestweber, Dietmar ^{[7
]}

Wild, Martin K. ^{[7
]}

Marcinko, Marie ^{[3
]}

Sobieszczuk, Peter ^{[3
]}

Stewart, Lauren ^{[3
]}

Lebus, Daniel ^{[3
]}

Gicquel, Brigitte ^{[2
]}

Neyrolles, Olivier ^{[1
,2
,5
]}

机构：

[1] Univ Toulouse 3, Univ Toulouse, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France

[2] Inst Pasteur, Mycobacterial Genet Unit, F-75724 Paris, France

[3] Scripps Res Inst, Dept Physiol Chem, Consortium Funct Glyc, La Jolla, CA 92037 USA

[4] Univ London Imperial Coll Sci Technol & Med, Div Mol Biosci, London SW7 2AZ, England

[5] Univ Toulouse 3, Univ Toulouse, CNRS, F-31077 Toulouse, France

[6] Colorado State Univ, Dept Microbiol Immunol & Pathol, Mycobacteria Res Labs, Ft Collins, CO 80523 USA

[7] Max Planck Inst Mol Biomed, D-48149 Munster, Germany

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 10期

基金：

英国惠康基金;

关键词：

C-TYPE LECTINS; TOLL-LIKE RECEPTORS; DENDRITIC CELL; IMMUNE-RESPONSE; MICE LACKING; MOUSE DC; RECOGNITION; INFECTION; DECTIN-1; MACROPHAGES;

D O I：

10.1084/jem.20090188

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The C-type lectin dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) mediates the innate immune recognition of microbial carbohydrates. We investigated the function of this molecule in the host response to pathogens in vivo, by generating mouse lines lacking the DC-SIGN homologues SIGNR1, SIGNR3, and SIGNR5. Resistance to Mycobacterium tuberculosis was impaired only in SIGNR3-deficient animals. SIGNR3 was expressed in lung phagocytes during infection, and interacted with M. tuber-culosis bacilli and mycobacterial surface glycoconjugates to induce secretion of critical host defense inflammatory cytokines, including tumor necrosis factor (TNF). SIGNR3 signaling was dependent on an intracellular tyrosine-based motif and the tyrosine kinase Syk. Thus, the mouse DC-SIGN homologue SIGNR3 makes a unique contribution to protection of the host against a pulmonary bacterial pathogen.

引用

页码：2205 / 2220

页数：16

共 58 条

[1] Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes [J].

Abadie, V ;

Badell, E ;

Douillard, P ;

Ensergueix, D ;

Leenen, PJM ;

Tanguy, M ;

Fiette, L ;

Saeland, S ;

Gicquel, B ;

Winter, N .

BLOOD, 2005, 106 (05) :1843-1850

[2] Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis [J].

Barreiro, LB ;

Neyrolles, O ;

Babb, CL ;

Tailleux, L ;

Quach, H ;

McElreavey, K ;

van Helden, PD ;

Hoal, EG ;

Gicquel, B ;

Quintana-Murci, L .

PLOS MEDICINE, 2006, 3 (02) :230-235

[3] Novel member of the CD209 (DC-SIGN) gene family in primates [J].

Bashirova, AA ;

Wu, L ;

Cheng, J ;

Martin, TD ;

Martin, MP ;

Benveniste, RE ;

Lifson, JD ;

KewalRamani, VN ;

Hughes, A ;

Carrington, M .

JOURNAL OF VIROLOGY, 2003, 77 (01) :217-227

[4] Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors [J].

Brightbill, HD ;

Libraty, DH ;

Krutzik, SR ;

Yang, RB ;

Belisle, JT ;

Bleharski, JR ;

Maitland, M ;

Norgard, MV ;

Plevy, SE ;

Smale, ST ;

Brennan, PJ ;

Bloom, BR ;

Godowski, PJ ;

Modlin, RL .

SCIENCE, 1999, 285 (5428) :732-736

[5]

Brown GD, 2006, NAT REV IMMUNOL, V6, P33, DOI 10.1038/nri1745

[6] Functional comparison of mouse CIRE/mouse DC-SIGN and human DC-SIGN [J].

Caminschi, I ;

Corbett, AJ ;

Zahra, C ;

Lahoud, M ;

Lucas, KM ;

Sofi, M ;

Vremec, D ;

Gramberg, T ;

Pöhlmann, S ;

Curtis, J ;

Handman, E ;

van Dommelen, SLH ;

Fleming, P ;

Degli-Esposti, MA ;

Shortman, K ;

Wright, MD .

INTERNATIONAL IMMUNOLOGY, 2006, 18 (05) :741-753

[7] DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production [J].

Caparros, Esther ;

Munoz, Pilar ;

Sierra-Filardi, Elena ;

Serrano-Gomez, Diego ;

Puig-Kroeger, Amaya ;

Rodriguez-Fernandez, Jose L. ;

Mellado, Mario ;

Sancho, Jaime ;

Zubiaur, Mercedes ;

Corbi, Angel L. .

BLOOD, 2006, 107 (10) :3950-3958

[8] Toll-like receptors control autophagy [J].

Delgado, Monica A. ;

Elmaoued, Rasha A. ;

Davis, Alexander S. ;

Kyei, George ;

Deretic, Vojo .

EMBO JOURNAL, 2008, 27 (07) :1110-1121

[9] Immunology of tuberculosis [J].

Flynn, JL ;

Chan, J .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :93-129

[10] TUMOR-NECROSIS-FACTOR-ALPHA IS REQUIRED IN THE PROTECTIVE IMMUNE-RESPONSE AGAINST MYCOBACTERIUM-TUBERCULOSIS IN MICE [J].

FLYNN, JL ;

GOLDSTEIN, MM ;

CHAN, J ;

TRIEBOLD, KJ ;

PFEFFER, K ;

LOWENSTEIN, CJ ;

SCHREIBER, R ;

MAK, TW ;

BLOOM, BR .

IMMUNITY, 1995, 2 (06) :561-572

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