Nonequilibrium Calcium Dynamics Regulate the Autonomous Firing Pattern of Rat Striatal Cholinergic Interneurons

被引:42
作者
Goldberg, Joshua A. [1 ]
Teagarden, Mark A. [1 ]
Foehring, Robert C. [2 ]
Wilson, Charles J. [1 ]
机构
[1] Univ Texas San Antonio, Dept Biol, San Antonio, TX 78249 USA
[2] Univ Tennessee, Dept Anat & Neurobiol, Hlth Sci Ctr, Memphis, TN 38163 USA
基金
美国国家卫生研究院;
关键词
NEOCORTICAL PYRAMIDAL NEURONS; ACTIVATED POTASSIUM CURRENTS; BOVINE CHROMAFFIN CELLS; SLOW AFTERHYPERPOLARIZATION; TIME-COURSE; PHOTOLYTIC MANIPULATION; INTRACELLULAR CALCIUM; HIPPOCAMPAL-NEURONS; VAGAL MOTONEURONS; CA2+ CHANNELS;
D O I
10.1523/JNEUROSCI.5582-08.2009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Striatal cholinergic interneurons discharge rhythmically in two patterns associated with different after hyperpolarization timescales, each dictated by a different calcium-dependent potassium current. Single spiking depends on a medium-duration after hyperpolarization (mAHP) generated by rapid SK currents that are associated with N-type calcium channels. Periodic bursting is driven by a delayed and slowly decaying afterhyperpolarization (sAHP) current associated with L-type channels. Using calcium imaging we show that the calcium transients underlying these currents exhibit two corresponding timescales throughout the somatodendritic tree. This result is not consistent with spatial compartmentalization of calcium entering through the two calcium channels and acting on the two potassium currents, or with differences in channel gating kinetics of the calcium dependent potassium currents. Instead, we show that nonequilibrium dynamics of calcium redistribution among cytoplasmic binding sites with different calcium binding kinetics can give rise to multiple timescales within the same cytoplasmic volume. The resulting independence of mAHP and sAHP currents allows cytoplasmic calcium to control two different and incompatible firing patterns (single spiking or bursting and pausing), depending on whether calcium influx is pulsatile or sustained. During irregular firing, calcium entry at both timescales can be detected, suggesting that an interaction between the medium and slow calcium-dependent afterhyperpolarizations may underlie this firing pattern.
引用
收藏
页码:8396 / 8407
页数:12
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