A novel borate fluorescent probe for rapid selective intracellular peroxynitrite imaging

被引：19
|
作者：
Wang, Minmin [1 ,3 ]
Wang, Chun [2 ,3 ]
Song, Wenwu [1 ]
Zhong, Weiting [1 ]
Sun, Tongming [1 ]
Zhu, Jinli [1 ]
Wang, Jin [1 ,3 ]
机构：
[1] Nantong Univ, Sch Chem & Chem Engn, Nantong 226019, Peoples R China
[2] Nantong Univ, Sch Text, Nantong 226019, Peoples R China
[3] Nantong Key Lab Intelligent & New Energy Mat, Nantong, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2021年 / 251卷
基金：
中国国家自然科学基金;
关键词：
ONOO-; detection; Benzyl borate; Fluorescent probe; Cell imaging; Fast response;
D O I：
10.1016/j.saa.2020.119398
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Peroxynitrite (ONOO-) is one of the species of reactive nitrogen (RNS), which plays an important role in antibacterial activity and signal transduction and other physiological and pathological processes. In this paper, based on the benzyl borate group, a new fluorescent probe capable of detecting ONOO- with high selectivity and sensitivity is designed, and the possible mechanism of the interaction between probe and ONOO- is proposed. The probe shows high fluorescence response to ONOO- in a wide pH range (7.0-11.5). Moreover, the probe exhibit good permeability, and the content of ONOO- in cancer cells and normal cells was successfully monitored. (C) 2020 Elsevier B.V. All rights reserved.
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收藏
页数：8
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