Impact of 18F-fluoro-deoxy-glucose positron emission tomography (FDG-PET) in recurrent colorectal cancer

被引：2

作者：

Metrard, G. ^{[1
,2
]}

Morel, O. ^{[1
]}

Girault, S. ^{[1
]}

Soulie, P. ^{[1
]}

Guerin-Meyer, V. ^{[1
]}

Lorimier, G. ^{[1
]}

Jeanguillaume, C. ^{[2
]}

Berthelot, C. ^{[2
]}

Parot-Schinkel, E. ^{[3
]}

Le Jeune, J-J ^{[2
]}

Gamelin, E. ^{[1
]}

机构：

[1] Ctr Paul Papin, F-49933 Angers 9, France

[2] CHU Angers, Nucl Med Serv, Angers, France

[3] CHU Angers, Ctr Rech Clin, Angers, France

来源：

MEDECINE NUCLEAIRE-IMAGERIE FONCTIONNELLE ET METABOLIQUE | 2009年 / 33卷 / 09期

关键词：

Colorectal cancer; PET; FDG; Recurrence; DECISION-MAKING; MANAGEMENT; METASTASES; RESECTION;

D O I：

10.1016/j.mednuc.2009.06.003

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Purpose. - The aim of the study was to evaluate the diagnostic performance, the prognosis factors and the therapeutic impact of 18F-FDG positron emission tomography (FDG-PET) in the detection of recurrent colorectal cancers. Methods. - Sixty PET/CT with 18F-FDG and CT were performed in 52 patients, at the Paul Papin cancer center between 2003 and 2005, following suspicion of colorectal cancer relapse. The FDG-PET impact on the clinical management was studied by examination of multidisciplinary concertations results. Survival analysis were realized with a mean follow up of 2.2 years. Results. - Recurrence was confirmed for 50 explorations by histologic (n = 32), radiologic (n = 14) or clinical (n = 4) findings. Twenty patients died during the time of the study. On a patient based analysis, FDG-PET sensitivity, specificity and overall accuracy were 90, 90, 90% respectively compared with 74,50 and 70% for CT. FDG-PET changed the clinical management in 18 cases (30%). A positive FDG-PET signal, more than one hepatic lesion, more than two lymph node lesions detected on FDG-PET and more than two hepatic lesions on CT were characterized as bad prognostic factors for survival. Multivariate analysis showed that the only independent bad prognostic factor was the FDG-PET detection of more than two liver lesions. Conclusion. - These results confirmed the important impact of FDG-PET in the clinical management of patients with a suspected recurrence of colorectal cancer. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：547 / 552

页数：6

共 20 条

[1] CLINICAL PERSPECTIVE OF HUMAN COLORECTAL-CANCER METASTASIS [J].

AUGUST, DA ;

OTTOW, RT ;

SUGARBAKER, PH .

CANCER AND METASTASIS REVIEWS, 1984, 3 (04) :303-324

[2] FDG PET evaluation of mucinous neoplasms: Correlation of FDG uptake with histopathologic features [J].

Berger, KL ;

Nicholson, SA ;

Dehdashti, F ;

Siegel, BA .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2000, 174 (04) :1005-1008

[3] CONTEMPORARY OPERATIVE MANAGEMENT OF PULMONARY METASTASES OF COLORECTAL ORIGIN [J].

BRISTER, SJ ;

DEVARENNES, B ;

GORDON, PH ;

SHEINER, NM ;

PYM, J .

DISEASES OF THE COLON & RECTUM, 1988, 31 (10) :786-792

[4]

Cohade C, 2003, J NUCL MED, V44, P1797

[5] PET diagnostic accuracy: Improvement with in-line PET-CT system: Initial results [J].

Hany, TF ;

Steinert, HC ;

Goerres, GW ;

Buck, A ;

von Schulthess, GK .

RADIOLOGY, 2002, 225 (02) :575-581

[6]

Huebner RH, 2000, J NUCL MED, V41, P1177

[7] Local recurrence of cancer of the rectum [J].

Huguier, M ;

Houry, S ;

Barrier, A .

AMERICAN JOURNAL OF SURGERY, 2001, 182 (05) :437-439

[8] Impact of 18F-FDG-positron emission tomography for decision making in colorectal cancer recurrences [J].

Imdahl, A ;

Reinhardt, MJ ;

Nitzsche, EU ;

Mix, M ;

Dingeldey, A ;

Einert, A ;

Baier, P ;

Farthmann, EH .

LANGENBECKS ARCHIVES OF SURGERY, 2000, 385 (02) :129-134

[9]

Kalff V, 2002, J NUCL MED, V43, P492

[10] Incidence and patterns of recurrence following curative resection for colorectal carcinoma [J].

Obrand, DI ;

Gordon, PH .

DISEASES OF THE COLON & RECTUM, 1997, 40 (01) :15-24

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