CLINICAL GUIDELINES FOR CRYOSUPERNATANT TRANSFUSIONS

被引：2

作者：

Galstyan, G. M. ^{[1
]}

Gaponova, T., V ^{[2
]}

Sherstnev, F. S. ^{[8
]}

Kupryashov, A. A. ^{[9
]}

Olovnikova, N., I ^{[3
]}

Zozulya, N., I ^{[4
]}

Troitskaya, V. V. ^{[5
,6
]}

Mazurok, V. A. ^{[10
]}

Pevtcov, D. E. ^{[11
]}

Salimov, E. L. ^{[12
]}

Trakhtman, P. E. ^{[13
]}

Savchenko, V. G. ^{[7
]}

机构：

[1] Natl Res Ctr Hematol, Dept Intens, Moscow 125167, Russia

[2] Natl Res Ctr Hematol, Dept Blood Cell Proc & Cryopreservat, Moscow 125167, Russia

[3] Natl Res Ctr Hematol, Lab Blood Format Physiol, Moscow 125167, Russia

[4] Natl Res Ctr Hematol, Sci & Consulting Dept Coagulopathies, Moscow 125167, Russia

[5] Natl Res Ctr Hematol, Dept Intens High Dose Chemotherapy Hemoblastosis, Moscow 125167, Russia

[6] Natl Res Ctr Hematol, Med Work, Moscow 125167, Russia

[7] Natl Res Ctr Hematol, Moscow 125167, Russia

[8] Fed Med & Biol Agcy Russia, Kirov Res Inst Hematol & Blood Transfus, Kirov 610027, Russia

[9] AN Bakulev Natl Med Res Ctr Cardiovasc Surg, Moscow 121552, Russia

[10] Almazov Natl Med Res Ctr, St Petersburg 197341, Russia

[11] IP Pavlov First St Petersburg State Med Univ, St Petersburg 197022, Russia

[12] IM Sechenov First Moscow State Med Univ, Moscow 119991, Russia

[13] Dmitry Rogachev Natl Res Ctr Pediat Hematol Oncol, Dept Blood Transfus Prod & Proc Hematopoiet Stem, Moscow 117198, Russia

来源：

GEMATOLOGIYA I TRANSFUZIOLOGIYA | 2020年 / 65卷 / 03期

关键词：

cryosupernatant; fibrinogen; factor VIII inhibitor; factor VIII; von Willebrand; ADAMTS; 13; thrombotic thrombocytopenic purpura; THROMBOTIC THROMBOCYTOPENIC PURPURA; CRYOPRECIPITATE-POOR PLASMA; VON-WILLEBRAND-FACTOR; FRESH-FROZEN PLASMA; REPLACEMENT FLUID; EXCHANGE;

D O I：

10.35754/0234-5730-2020-65-3-351-359

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction. Cryosupernatant is blood component. Cryosupernatant is the supernatant plasma removed during the preparation of cryoprecipitate. Aim. To provide information on the composition and methods of production, storage, transportation and clinical use of Cryosupernatant. General findings. In comparison with fresh frozen plasma (FFP) and cryoprecipitate, Cryosupernatant plasma is depleted in factor VIII, fibrinogen factor von Willebrand (VWF). Cryosupernatant is deficient in high molecular weight multimers of VWF, but contains VWF metalloproteinase. The concentrations of factor V, antithrombin III, albumin and immunoglobulins are the same as in FFP and cryoprecipitate. The indications for Cryosupernatant transfusions are massive blood loss in patients with factor VIII inhibitor, plasma exchange in patients with thrombotic thrombocytopenic purpura. For children the doses of Cryosupernatant should be 10-15 mL/kg.

引用

页码：351 / 359

页数：9

共 18 条

[1] Therapeutic plasma exchange for the treatment of thrombotic thrombocytopenic purpura: A retrospective multicenter study [J].

Altuntas, Fevzi ;

Aydogdu, Ismet ;

Kabukcu, Sibel ;

Kocyigit, Ismail ;

Cikim, Kerim ;

Sari, Ismail ;

Erkut, M. Ali ;

Eser, Bulent ;

Ozturk, Ahmet ;

Kaya, Emin ;

Cetin, Mustafa ;

Keskin, Ali ;

Unal, Ali .

TRANSFUSION AND APHERESIS SCIENCE, 2007, 36 (01) :57-67

[2] Stability of relevant plasma protein activities in cryosupernatant plasma units during refrigerated storage for up to 5 days postthaw [J].

Bhakta, Varsha ;

Jenkins, Craig ;

Ramirez-Arcos, Sandra ;

Sheffield, William P. .

TRANSFUSION, 2014, 54 (02) :418-425

[3]

Canadian Blood Service, 2018, CIRC INF US HUM BLOO

[4] Analysis of the products of cryoprecipitation: RiCoF is deficient in cryosupernatant plasma [J].

Freedman, M. ;

Rock, G. .

TRANSFUSION AND APHERESIS SCIENCE, 2010, 43 (02) :179-182

[5] ADAMTS13 unbound to larger von Willebrand factor multimers in cryosupernatant: implications for selection of plasma preparations for thrombotic thrombocytopenic purpura treatment [J].

Hori, Yuji ;

Hayakawa, Masaki ;

Isonishi, Ayami ;

Soejima, Kenji ;

Matsumoto, Masanori ;

Fujimura, Yoshihiro .

TRANSFUSION, 2013, 53 (12) :3192-3202

[6] Combination of Fresh Frozen Plasma and Cryosupernatant Plasma for Therapeutic Plasma Exchange in Thrombotic Thrombocytopenic Purpura: A Single Institution Experience [J].

Lin, Qiuyan ;

Fan, Liping ;

Huang, Haobo ;

Zeng, Feng ;

Fu, Danhui ;

Wei, Shijin .

BIOMED RESEARCH INTERNATIONAL, 2019, 2019

[7] Treatment of acquired Thrombotic Thrombocytopenic Purpura in the US remains heterogeneous: Current and future points of clinical equipoise [J].

Mazepa, Marshall A. ;

Raval, Jay S. ;

Brecher, Mark E. ;

Park, Yara A. .

JOURNAL OF CLINICAL APHERESIS, 2018, 33 (03) :291-296

[8]

MOAKE JL, 1985, BLOOD, V65, P1232

[9] Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant [J].

O'Shaughnessy, DF ;

Atterbury, C ;

Maggs, PB ;

Murphy, M ;

Thomas, D ;

Yates, S ;

Williamson, LM .

BRITISH JOURNAL OF HAEMATOLOGY, 2004, 126 (01) :11-28

[10] Cryosupernatant and Immunosuppression as Effective Alternative Therapies for TTP in Three Pediatric SLE Patients [J].

Palaniappan, Pragathesh ;

Lionel, Arul Premanand ;

Agarwal, Indira ;

Mathai, Sarah ;

Mathew, Leni ;

Agarwal, Sanwar ;

Keni, Purva ;

Khubchandani, Raju ;

Kumar, Sathish .

INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION, 2014, 30 :S232-S236

← 1 2 →