DNA methylation patterns of adult survivors of adolescent/young adult Hodgkin lymphoma compared to their unaffected monozygotic twin

被引：12
|
作者：
Wang, Jun [1 ]
Van Den Berg, David [1 ]
Hwang, Amie E. [1 ]
Weisenberger, Daniel [2 ]
Triche, Timothy [3 ,4 ]
Nathwani, Bharat N. [5 ]
Conti, David, V [1 ]
Siegmund, Kim [1 ]
Mack, Thomas M. [1 ,6 ]
Horvath, Steve [7 ]
Cozen, Wendy [1 ,6 ]
机构：
[1] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA
[2] Univ Southern Calif, Norris Comprehens Canc Ctr, Los Angeles, CA USA
[3] Univ Southern Calif, Dept Translat Genom, Los Angeles, CA USA
[4] Van Andel Res Inst, Ctr Epigenet, Grand Rapids, MI USA
[5] City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
[6] Univ Southern Calif, Dept Pathol, Los Angeles, CA USA
[7] Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA USA
来源：
LEUKEMIA & LYMPHOMA | 2019年 / 60卷 / 06期
关键词：
Hodgkin lymphoma; AYA; survivors; twins; blood; saliva; DNA methylation; LONG-TERM SURVIVORS; CHILDHOOD-CANCER; DRUG-RESISTANCE; BREAST-CANCER; RISK; DISEASE; AGE; MORTALITY; REVEALS; FATIGUE;
D O I：
10.1080/10428194.2018.1533128
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNA methylation (DNAm) silences gene expression and may play a role in immune dysregulation that is characteristic of adolescent/young adult Hodgkin lymphoma (AYAHL). We used the Infinium HumanMethylation27 BeadChip to quantify DNAm in blood (N=9 pairs, mean age 57.4 y) or saliva (N=36 pairs, mean age 50.0 y) from long-term AYAHL survivors and their unaffected co-twins. Epigenetic aging (DNAm age) was calculated using previously described methods and compared between survivors and co-twins using paired t-tests and analyses were stratified by sample type, histology, sex, age at sample collection and time since diagnosis. Differences in blood DNAm age were observed between survivors and unaffected co-twins (64.1 vs. 61.3 years, respectively, p=.04), especially in females (p=.01); no differences in saliva DNAm age were observed. Survivors and co-twins had 74 (in blood DNA) and 6 (in saliva DNA) differentially methylated loci. Our results suggest persistent epigenetic aging in AYAHL survivors long after HL cure.
引用
收藏
页码：1429 / 1437
页数：9
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