Acute myeloid leukemia: current progress and future directions

被引：526

作者：

Kantarjian, Hagop ^{[1
]}

Kadia, Tapan ^{[1
]}

DiNardo, Courtney ^{[1
]}

Daver, Naval ^{[1
]}

Borthakur, Gautam ^{[1
]}

Jabbour, Elias ^{[1
]}

Garcia-Manero, Guillermo ^{[1
]}

Konopleva, Marina ^{[1
]}

Ravandi, Farhad ^{[1
]}

机构：

[1] MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

来源：

BLOOD CANCER JOURNAL | 2021年 / 11卷 / 02期

关键词：

ACUTE PROMYELOCYTIC LEUKEMIA; MINIMAL RESIDUAL DISEASE; LOW-DOSE CYTARABINE; TRANS-RETINOIC ACID; RISK MYELODYSPLASTIC SYNDROME; INDUCTION PROLONGS SURVIVAL; STEM-CELL TRANSPLANTATION; INDIVIDUAL PATIENT DATA; GEMTUZUMAB OZOGAMICIN; ARSENIC TRIOXIDE;

D O I：

10.1038/s41408-021-00425-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Progress in the understanding of the biology and therapy of acute myeloid leukemia (AML) is occurring rapidly. Since 2017, nine agents have been approved for various indications in AML. These included several targeted therapies like venetoclax, FLT3 inhibitors, IDH inhibitors, and others. The management of AML is complicated, highlighting the need for expertise in order to deliver optimal therapy and achieve optimal outcomes. The multiple subentities in AML require very different therapies. In this review, we summarize the important pathophysiologies driving AML, review current therapies in standard practice, and address present and future research directions.

引用

页数：25

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