Egg yolk IgY antibodies: A therapeutic intervention against group A rotavirus in calves

被引：27

作者：

Vega, C. ^{[1
]}

Bok, M. ^{[1
]}

Saif, L. ^{[2
]}

Fernandez, F. ^{[1
]}

Parreno, V. ^{[1
]}

机构：

[1] CICV & A INTA, Inst Virol, RA-1712 Castelar CC 25, Buenos Aires, Argentina

[2] Ohio State Univ, Ohio Agr Res & Dev Ctr, FAHRP, Columbus, OH 43210 USA

来源：

RESEARCH IN VETERINARY SCIENCE | 2015年 / 103卷

关键词：

Bovine; Rotavirus; Passive immunity; Chicken antibodies; IgY; BOVINE ROTAVIRUS; MATERNAL ANTIBODIES; PASSIVE PROTECTION; INDUCED DIARRHEA; NEONATAL CALVES; DAIRY HERDS; COLOSTRUM; RESPONSES; SERUM; BEEF;

D O I：

10.1016/j.rvsc.2015.09.005

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Bovine group A rotavirus (RVA) is considered the major cause of diarrhea in intensively reared neonatal calves. Chicken egg yolk antibodies (IgY) are efficient in protecting neonatal calves from RVA diarrhea; however, the value of this intervention in calves once diarrhea has appeared is unclear. The aim of the present study was to evaluate the application of RVA-specific IgY as a passive treatment in those cases. The experimental groups were: G1 = RVA-specific IgY treatment; G2 = no Ab treatment; and G3 = colostrum deprived + no Ab treatment. IgY treatment significantly reduced virus shedding, diarrhea duration and severity compared to G2 and G3 calves. However, it caused a partial suppression of systemic Ab responses to RVA that could be associated with less severe diarrhea. The oral treatment with IgY for 7 days was associated with significantly higher antibody secreting cell responses in the calves compared with other groups of animals. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1 / 10

页数：10

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