Tubulin Detyrosination An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy

被引:3
作者
Margulies, Kenneth B. [1 ,2 ,3 ]
Prosser, Benjamin L. [2 ,3 ,4 ]
机构
[1] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Physiol, Philadelphia, PA 19104 USA
[3] Univ Penn, Perelman Sch Med, Cardiovasc Inst, Philadelphia, PA 19104 USA
[4] Univ Penn, Perelman Sch Med, Penn Muscle Inst, Philadelphia, PA 19104 USA
关键词
Editorials; cardiomegaly; cardiomyopathy; hypertrophic; mutation; myosins;
D O I
10.1161/CIRCHEARTFAILURE.120.008006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:56 / 58
页数:3
相关论文
共 9 条
[1]   Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium [J].
Caporizzo, Matthew A. ;
Chen, Christina Yingxian ;
Bedi, Ken ;
Margulies, Kenneth B. ;
Prosser, Benjamin L. .
CIRCULATION, 2020, 141 (11) :902-915
[2]   Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes [J].
Chen, Christina Yingxian ;
Salomon, Alexander K. ;
Caporizzo, Matthew A. ;
Curry, Sam ;
Kelly, Neil A. ;
Bedi, Kenneth ;
Bogush, Alexey, I ;
Kramer, Elisabeth ;
Schlossarek, Saskia ;
Janiak, Philip ;
Moutin, Marie-Jo ;
Carrier, Lucie ;
Margulies, Kenneth B. ;
Prosser, Benjamin L. .
CIRCULATION RESEARCH, 2020, 127 (02) :E14-E27
[3]   Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure [J].
Chen, Christina Yingxian ;
Caporizzo, Matthew A. ;
Bedi, Kenneth ;
Vite, Alexia ;
Bogush, Alexey, I ;
Robison, Patrick ;
Heffler, Julie G. ;
Salomon, Alex K. ;
Kelly, Neil A. ;
Babu, Apoorva ;
Morley, Michael P. ;
Margulies, Kenneth B. ;
Prosser, Benjamin L. .
NATURE MEDICINE, 2018, 24 (08) :1225-+
[4]   Surgery insight: septal myectomy for obstructive hypertrophic cardiomyopathy - the Mayo Clinic experience [J].
Dearani, Joseph A. ;
Ommen, Steve R. ;
Gersh, Bernard J. ;
Schaff, Hartzell V. ;
Danielson, Gordon K. .
NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2007, 4 (09) :503-512
[5]   Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytes [J].
Kurdi, Mazen ;
Bowers, Mark C. ;
Dado, Joana ;
Booz, George W. .
FREE RADICAL BIOLOGY AND MEDICINE, 2007, 42 (04) :474-481
[6]   Cardiac hypertrophy of unknown cause - A study of the clinical and pathologic features in ten adults [J].
Levy, RL ;
Von Glahn, WC .
AMERICAN HEART JOURNAL, 1944, 28 :714-741
[7]   Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes [J].
Robison, Patrick ;
Caporizzo, Matthew A. ;
Ahmadzadeh, Hossein ;
Bogush, Alexey I. ;
Chen, Christina Yingxian ;
Margulies, Kenneth B. ;
Shenoy, Vivek B. ;
Prosser, Benjamin L. .
SCIENCE, 2016, 352 (6284)
[8]   Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy [J].
Schuldt, Maike ;
Pei, Jiayi ;
Harakalova, Magdalena ;
Dorsch, Larissa M. ;
Schlossarek, Saskia ;
Mokry, Michal ;
Knol, Jaco C. ;
Pham, Thang, V ;
Schelfhorst, Tim ;
Piersma, Sander R. ;
Dos Remedios, Cris ;
Dalinghaus, Michiel ;
Michels, Michelle ;
Asselbergs, Folkert W. ;
Moutin, Marie-Jo ;
Carrier, Lucie ;
Jimenez, Connie R. ;
van der Velden, Jolanda ;
Kuster, Diederik W. D. .
CIRCULATION-HEART FAILURE, 2021, 14 (01) :39-55
[9]   Microtubules regulate cardiomyocyte transversal Young's modulus [J].
Swiatlowska, Pamela ;
Sanchez-Alonso, Jose L. ;
Wright, Peter T. ;
Novak, Pavel ;
Gorelik, Julia .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (06) :2764-2766