68Ga-FAPI PET/CT Versus 68Ga-DOTATATE PET/CT in the Evaluation of a Patient With Neuroendocrine Tumor

被引：23
作者：
Komek, Halil [1 ]
Gundogan, Cihan [1 ]
Can, Canan [1 ]
机构：
[1] Univ Hlth Sci, Gazi Yasargil Training & Res Hosp, Dept Nucl Med, TR-21070 Diyarbakir, Turkey
来源：
CLINICAL NUCLEAR MEDICINE | 2021年 / 46卷 / 05期
关键词：
Ga-68-DOTATE; Ga-68-FAPI; neuroendocrine tumors; PET/CT;
D O I：
10.1097/RLU.0000000000003490
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Ga-68-FAPI (fibroblast activation protein-specific inhibitor) PET/CT was performed in a 56-year-old man with multiple liver masses, which were confirmed grade 2 well-differentiated neuroendocrine tumors with liver Tru-Cut biopsy. With Ga-68-DOTATE PET/CT, primary tumor in the pancreas, multiple metastases in the liver and metastatic portocaval lymph node were detected. In Ga-68-FAPI PET/CT imaging performed for comparison, it was seen that metastatic lesions in the liver were distinguished much better because of low background activity, and the primary tumor and metastatic lymph node were clearly selected. This case suggested that FAPI-bounded radionuclides may be useful in the evaluation and targeted therapy of neuroendocrine tumors.
引用
收藏
页码：E290 / E292
页数：3
相关论文
共 9 条
[1]   Comparison of [68Ga]Ga-DOTA-FAPI-04 and [18F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer [J].
Chen, Haojun ;
Pang, Yizhen ;
Wu, Jingxun ;
Zhao, Liang ;
Hao, Bing ;
Wu, Jing ;
Wei, Jihong ;
Wu, Siming ;
Zhao, Long ;
Luo, Zuoming ;
Lin, Xuehua ;
Xie, Chengrong ;
Sun, Long ;
Lin, Qin ;
Wu, Hua .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 47 (08) :1820-1832
[2]   68Ga-FAPI PET/CT: Biodistribution and Preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting Agents in Patients with Various Cancers [J].
Giesel, Frederik L. ;
Kratochwil, Clemens ;
Lindner, Thomas ;
Marschalek, Manfred M. ;
Loktev, Anastasia ;
Lehnert, Wencke ;
Debus, Juergen ;
Jaeger, Dirk ;
Flechsig, Paul ;
Altmann, Annette ;
Mier, Walter ;
Haberkorn, Uwe .
JOURNAL OF NUCLEAR MEDICINE, 2019, 60 (03) :386-392
[3]   68Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer [J].
Kratochwil, Clemens ;
Flechsig, Paul ;
Lindner, Thomas ;
Abderrahim, Labidi ;
Altmann, Annette ;
Mier, Walter ;
Adeberg, Sebastian ;
Rathke, Hendrik ;
Roehrich, Manuel ;
Winter, Hauke ;
Plinkert, Peter K. ;
Marme, Frederik ;
Lang, Matthias ;
Kauczor, Hans-Ulrich ;
Jaeger, Dirk ;
Debus, Juergen ;
Haberkorn, Uwe ;
Giesel, Frederik L. .
JOURNAL OF NUCLEAR MEDICINE, 2019, 60 (06) :801-805
[4]   Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein [J].
Lindner, Thomas ;
Loktev, Anastasia ;
Altmann, Annette ;
Giesel, Frederik ;
Kratochwil, Clemens ;
Debus, Juergen ;
Jaeger, Dirk ;
Mier, Walter ;
Haberkorn, Uwe .
JOURNAL OF NUCLEAR MEDICINE, 2018, 59 (09) :1415-1422
[5]   A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts [J].
Loktev, Anastasia ;
Lindner, Thomas ;
Mier, Walter ;
Debus, Juergen ;
Altmann, Annette ;
Jaeger, Dirk ;
Giesel, Frederik ;
Kratochwil, Clemens ;
Barthe, Philippe ;
Roumestand, Christian ;
Haberkorn, Uwe .
JOURNAL OF NUCLEAR MEDICINE, 2018, 59 (09) :1423-1429
[6]   IDH-wildtype glioblastomas and grade III/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein-specific PET/CT [J].
Roehrich, Manuel ;
Loktev, Anastasia ;
Wefers, Annika K. ;
Altmann, Annette ;
Paech, Daniel ;
Adeberg, Sebastian ;
Windisch, Paul ;
Hielscher, Thomas ;
Flechsig, Paul ;
Floca, Ralf ;
Leitz, Dominik ;
Schuster, Julius P. ;
Huber, Peter E. ;
Debus, Juergen ;
von Deimling, Andreas ;
Lindner, Thomas ;
Haberkorn, Uwe .
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2019, 46 (12) :2569-2580
[7]   Health-Related Quality of Life in Patients With Progressive Midgut Neuroendocrine Tumors Treated With 177Lu-Dotatate in the Phase III NETTER-1 Trial [J].
Strosberg, Jonathan ;
Wolin, Edward ;
Chasen, Beth ;
Kulke, Matthew ;
Bushnell, David ;
Caplin, Martyn ;
Baum, Richard P. ;
Kunz, Pamela ;
Hobday, Timothy ;
Hendifar, Andrew ;
Oberg, Kjell ;
Sierra, Maribel Lopera ;
Thevenet, Thomas ;
Margalet, Ines ;
Ruszniewski, Philippe ;
Krenning, Eric .
JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (25) :2578-+
[8]   ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Radiological, Nuclear Medicine and Hybrid Imaging [J].
Sundin, Anders ;
Arnold, Rudolf ;
Baudin, Eric ;
Cwikla, Jaroslaw B. ;
Eriksson, Barbro ;
Fanti, Stefano ;
Fazio, Nicola ;
Giammarile, Francesco ;
Hicks, Rodney J. ;
Kjaer, Andreas ;
Krenning, Eric ;
Kwekkeboom, Dik ;
Lombard-Bohas, Catherine ;
O'Connor, Juan M. ;
O'Toole, Dermot ;
Rockall, Andrea ;
Wiedenmann, Bertram ;
Valle, Juan W. ;
Vullierme, Marie-Pierre .
NEUROENDOCRINOLOGY, 2017, 105 (03) :212-244
[9]   68Ga-FAPI-04 Accumulation in Myocardial Infarction in a Patient With Neuroendocrine Carcinoma [J].
Zhu, Wenjia ;
Guo, Fan ;
Wang, Yawen ;
Ding, Haiyan ;
Huo, Li .
CLINICAL NUCLEAR MEDICINE, 2020, 45 (12) :1020-1022
1