The role of Fibrinogen-like proteins in Cancer

被引：52
作者：
Li, Xiaobing [1 ]
Xiao, Zhangang [1 ,2 ]
Yu, Jing [1 ,2 ]
Li, Jing [3 ]
Shen, Jing [1 ,2 ]
Du, Fukuan [1 ,2 ]
Wu, Xu [1 ,2 ]
Li, Mingxing [1 ,2 ]
Chen, Yu [1 ,2 ]
Cho, Chi Hin [1 ,2 ]
Li, Xiaobing [1 ]
Xiao, Zhangang [1 ,2 ]
Zhao, Yueshui [1 ,2 ,4 ]
机构：
[1] Southwest Med Univ, Mol Pharmacol Lab, Dept Pharmacol, Sch Pharm, Luzhou 646000, Sichuan, Peoples R China
[2] South Sichuan Inst Translat Med, Luzhou 646000, Sichuan, Peoples R China
[3] Southwest Med Univ, Dept Hematol & Oncol, Hosp TCM, Luzhou, Sichuan, Peoples R China
[4] Southwest Med Univ, Dept Pharm, Affiliated Hosp, Luzhou 646000, Sichuan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2021年 / 17卷 / 04期
基金：
中国国家自然科学基金;
关键词：
FGF1; FGF2; Cancer; PROMOTES TUMOR PROGRESSION; T-CELL; HEPATOCELLULAR-CARCINOMA; FUNCTIONAL EXPRESSION; MOLECULAR-CLONING; INTERFERON-GAMMA; TNF-ALPHA; FGL2; GENE; PROTHROMBINASE;
D O I：
10.7150/ijbs.56748
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fibrinogen-associated protein (FREP) family is a family of proteins with a fibrin domain at the carboxyl terminus. Recent investigations illustrated that two members of FREP family, fibrinogen-like protein-1 (FGL1) and fibrinogen-like protein-2 (FGL2), play crucial roles in cancer by regulating the proliferation, invasion, and migration of tumor cells, or regulating the functions of immune cells in tumor microenvironment. Meanwhile, they are potential targets for medical intervention of tumor development. In this review, we discussed the structure, and the roles of FGL1 and FGL2 in tumors, especially the roles in regulating immune cell functions.
引用
收藏
页码：1079 / 1087
页数：9
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