Vitamin B6 status, deficiency and its consequences -: an overview

被引:5
|
作者
Spinneker, A.
Sola, R.
Lemmen, V.
Castillo, M. J.
Pietrzik, K.
Gonzalez-Gross, M.
机构
[1] Univ Politecn Madrid, Fac CC Act Fis & Deporte, E-28040 Madrid, Spain
[2] Univ Granada, Fac Med, Grp Effects 262, Granada, Spain
[3] Univ Bonn, Inst Ernahrungs & Lebensmittelwissensch, D-5300 Bonn, Germany
关键词
vitamin B-6; coenzyme; elderly; homocysteine; vitamin B; deficiency;
D O I
暂无
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Vitamin B-6 is thought to be a most versatile coenzyme that participates in more than 100 biochemical reactions. It is involved in amino acid and homocysteine metabolism, glucose and lipid metabolism, neurotransmitter production and DNA/RNA synthesis. Vitamin B-6 can also be a modulator of gene expression. Nowadays, clinically evident vitamin B-6 deficiency is not a common disorder, at least in the general population. Nevertheless, a subclinical, undiagnosed deficiency may be present in some subjects, particularly in the elderly. Objective: This review gives a complete overview over the metabolism and interactions of vitamin B-6 Further, we show which complications and deficiency symptoms can occur due to a lack of vitamin B-6 and possibilities for public health and supplemental interventions. Methods: The database Medline (www.nevi.nlm.nih.gov) was searched for terms like "vitamin B-6", "pyridoxal", "cancer", "homocysteine", etc. For a complete understanding, we included studies with early findings from the forties as well as recent results from 2006. These studies were summarised and compared in different chapters. Results and conclusion: In fact, it has been proposed that suboptimal vitamin B-6 status is associated with certain diseases that particularly afflict the elderly population: impaired cognitive function, Alzheimer's disease, cardiovascular disease, and different types of cancer. Some of these problems may be related to the elevated homocysteine concentrations associated to vitamin B-6 deficiency, but there is also evidence for other mechanisms independent of homocysteine by which a suboptimal vitamin B-6 status could increase the risk for these chronic diseases.
引用
收藏
页码:7 / 24
页数:18
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