Synthesis, Characterization, and Antimicrobial Evaluation of Novel 4-Pyrrol-1-yl-5,6,7,8-tetrahydro-pyrido[4′,3′:4,5] Thieno[2,3-d]pyrimidine Derivatives

被引：12

作者：

Parmar, Kokila ^{[1
]}

Suthar, Bharat ^{[1
]}

Suthar, Arun ^{[1
]}

Maheta, Abhay ^{[2
]}

机构：

[1] Hemchandracharya N Gujarat Univ, Dept Chem, Patan 384265, Gujarat, India

[2] Enum Nostrum Remedis, Bombay 400059, Maharashtra, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 05期

关键词：

CHEMISTRY; EXPLORATION; UREAS;

D O I：

10.1002/jhet.190

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel 7-alkyl/aryl sulfonyl-4-pyrrol-1-yl-5,6,7,8-tetrahydro-pyrido[4',3':4,5]thieno[2,3-d] pyrimidine 6 were synthesized for evaluation of their antibacterial and antifungal activity. The structures were determined by IR, NMR, mass spectroscopy, and elemental analysis. They were screened for activities against bacterial and fungal strains.

引用

页码：975 / 979

页数：5

共 31 条

[1] Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4(3H)-ones [J].

Alagarsamy, V. ;

Meena, S. ;

Ramseshu, K. V. ;

Solomon, V. R. ;

Thirumurugan, K. ;

Dhanabal, K. ;

Murugan, M. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (11) :1293-1300

[2]

ALEEM G, 1996, J MED CHEM, V39, P3228

[3]

BROWN DJ, 1988, CHEM HETEROCYCLIC CO, V24, P730

[4] Synthesis and preliminary evaluation of some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-d]pyrimidin-4-ones as antimicrobial agents [J].

Chambhare, RV ;

Khadse, BG ;

Bobde, AS ;

Bahekar, RH .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (01) :89-100

[5] Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors [J].

Dai, YJ ;

Guo, Y ;

Frey, RR ;

Ji, ZQ ;

Curtin, ML ;

Ahmed, AA ;

Albert, DH ;

Arnold, L ;

Arries, SS ;

Barlozzari, T ;

Bauch, JL ;

Bouska, JJ ;

Bousquet, PF ;

Cunha, GA ;

Glaser, KB ;

Guo, J ;

Li, JL ;

Marcotte, PA ;

Marsh, KC ;

Moskey, MD ;

Pease, LJ ;

Stewart, KD ;

Stoll, VS ;

Tapang, P ;

Wishart, N ;

Davidsen, SK ;

Michaelides, MR .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (19) :6066-6083

[6] CHEMISTRY OF PYRAZOLOPYRIMIDINES [J].

ELNAGDI, MH ;

ELMOGHAYAR, MRH ;

ELGEMEIE, GEH .

ADVANCES IN HETEROCYCLIC CHEMISTRY, 1987, 41 :319-376

[7] 2-AMINO-THIOPHENE AUS METHYLENAKTIVEN NITRILEN CARBONYLVERBINDUNGEN UND SCHWEFEL [J].

GEWALD, K ;

SCHINKE, E ;

BOTTCHER, H .

CHEMISCHE BERICHTE-RECUEIL, 1966, 99 (01) :94-&

[8] Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase [J].

Grunewald, Gary L. ;

Seim, Mitchell R. ;

Bhat, Seema R. ;

Wilson, Marc E. ;

Criscione, Kevin R. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (01) :542-559

[9]

GUO ZZ, 2001, BIOORG MED CHEM LETT, V11, P2071

[10] Design and synthesis of 3-pyrazolyl-thiophene, thieno[2,3-d]pyrimidines as new bioactive and pharmacological activities [J].

Hafez, H. N. ;

El-Gazzar, A. B. A. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (19) :5222-5227

← 1 2 3 4 →