Mammary stem cells and parity-induced breast cancer protection-new insights

被引：22
作者：
Dall, Genevieve [1 ,2 ]
Risbridger, Gail [2 ]
Britt, Kara [1 ,2 ,3 ]
机构：
[1] Peter MacCallum Canc Ctr, Metastasis Res Lab, 7 St Andrews Pl, East Melbourne 3002, Australia
[2] Monash Univ, Dept Anat & Dev Biol, Wellington Rd, Clayton, Vic 3800, Australia
[3] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic, Australia
来源：
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2017年 / 170卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
Breast cancer; Parity; Mammary stem cells; ATOMIC-BOMB SURVIVORS; GLAND DEVELOPMENT; HORMONE-RECEPTOR; RISK-FACTORS; REPRODUCTIVE FACTORS; TRANSIENT INCREASE; PERSISTENT CHANGES; 1ST BIRTH; PREGNANCY; MOUSE;
D O I：
10.1016/j.jsbmb.2016.02.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Parity (childbearing) significantly decreases a woman's risk of breast cancer and the protective effect is greater if the woman is younger and has more children. The mechanism/s of parity-induced protection are not known. Although several factors are postulated to play a role, we discuss how a reduction in the number of mammary stem cells (MaSCs) may lead to a reduction in breast cancer risk in parous women. Firstly we review the epidemiology linking childbearing to reduced breast cancer risk and discuss how additional births, a young age at first full term birth, and breastfeeding impact the protection. We then detail the mouse and human studies implicating MaSC in parity induced protection and the in-vivo work being performed in mice to directly investigate the effect of parity on MaSC. Finally we discuss the transplant and lineage tracing experiments assessing MaSC activity according to parity and the need to define if MaSC are indeed more carcinogen sensitive than mature mammary epithelial cells. Continuing and future studies attempting to define the parity induced mechanisms will aid in the development of preventative therapies. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：54 / 60
页数：7
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