Untemplated oligoadenylation promotes degradation of RISC-cleaved transcripts

被引:70
作者
Ibrahim, Fadia [1 ]
Rohr, Jennifer [1 ]
Jeong, Won-Joong [1 ]
Hesson, Jennifer [1 ]
Cerutti, Heriberto [1 ]
机构
[1] Univ Nebraska, Lincoln, NE 68588 USA
关键词
D O I
10.1126/science.1135268
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In an algal species, a polyadenylate polymerase adds adenines to RNA fragments, stimulating RNA degradation.
引用
收藏
页码:1893 / 1893
页数:1
相关论文
共 7 条
  • [1] A member of the polymerase β nucleotidyltransferase superfamily is required for RNA interference in C-elegans
    Chen, CCG
    Simard, MJ
    Tabara, H
    Brownell, DR
    McCollough, JA
    Mello, CC
    [J]. CURRENT BIOLOGY, 2005, 15 (04) : 378 - 383
  • [2] RNA degradation by the exosome is promoted by a nuclear polyade nylation complex
    LaCava, J
    Houseley, J
    Saveanu, C
    Petfalski, E
    Thompson, E
    Jacquier, A
    Tollervey, D
    [J]. CELL, 2005, 121 (05) : 713 - 724
  • [3] Methylation protects miRNAs and siRNAs from a 3′-end uridylation activity in Arabildopsis
    Li, JJ
    Yang, ZY
    Yu, B
    Liu, J
    Chen, XM
    [J]. CURRENT BIOLOGY, 2005, 15 (16) : 1501 - 1507
  • [4] Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs
    Motamedi, MR
    Verdel, A
    Colmenares, SU
    Gerber, SA
    Gygi, SP
    Moazed, D
    [J]. CELL, 2004, 119 (06) : 789 - 802
  • [5] Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome
    Orban, TI
    Izaurralde, E
    [J]. RNA, 2005, 11 (04) : 459 - 469
  • [6] Uridine addition after microRNA-directed cleavage
    Shen, BZ
    Goodman, HM
    [J]. SCIENCE, 2004, 306 (5698) : 997 - 997
  • [7] Ribo-gnome: The big world of small RNAs
    Zamore, PD
    Haley, B
    [J]. SCIENCE, 2005, 309 (5740) : 1519 - 1524