Is inflammatory bowel disease in dogs and cats associated with a Th1 or Th2 polarization?

被引：26

作者：

Heimann, Romy M. ^{[1
]}

Suchodolski, Jan S. ^{[1
]}

机构：

[1] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Small Anim Clin Sci, Gastrointestinal Lab, MS 4474, College Stn, TX 77843 USA

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2015年 / 168卷 / 3-4期

关键词：

Canine; Chronic enteropathy; Inflammatory bowel disease; Th1; Th2; Th17; CYTOKINE MESSENGER-RNA; DUODENAL MUCOSA; GENE-EXPRESSION; QUANTIFICATION; BIOPSIES;

D O I：

10.1016/j.vetimm.2015.10.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mucosal immunity involves complex interactions to generate either immune tolerance or active immune responses. An imbalance of pro- and anti-inflammatory cytokines and chemokines that drive the recruitment of immune cells to the intestinal mucosa are a key characteristic of inflammatory bowel disease in humans, where distinctive helper-T-lymphocyte profiles help to discriminate between Crohn's disease and ulcerative colitis. This review evaluates the current veterinary literature to determine whether a Th1/Th2 (and possibly also Th17) polarization also exists in canine and feline inflammatory bowel disease. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：131 / 134

页数：4

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