The Effects of Lactulose Supplementation to Enteral Feedings in Premature Infants: A Pilot Study

被引：37

作者：

Riskin, Arieh ^{[1
]}

Hochwald, Ori ^{[1
]}

Bader, David ^{[1
]}

Srugo, Isaac ^{[2
,3
]}

Naftali, Gabi ^{[4
]}

Kugelman, Amir ^{[1
]}

Cohen, Ella ^{[3
]}

Mor, Frida ^{[1
]}

Kaufman, Bela ^{[1
]}

Shaoul, Ron ^{[5
]}

机构：

[1] Technion Israel Inst Technol, Dept Neonatol, Rappaport Fac Med, Bnai Zion Med Ctr, IL-31048 Haifa, Israel

[2] Technion Israel Inst Technol, Dept Pediat, Rappaport Fac Med, Bnai Zion Med Ctr, IL-31048 Haifa, Israel

[3] Technion Israel Inst Technol, Dept Microbiol, Rappaport Fac Med, Bnai Zion Med Ctr, IL-31048 Haifa, Israel

[4] Technion Israel Inst Technol, Dept Pharm, Rappaport Fac Med, Bnai Zion Med Ctr, IL-31048 Haifa, Israel

[5] Technion Israel Inst Technol, Dept Pediat Gastroenterol, Rappaport Fac Med, Bnai Zion Med Ctr, IL-31048 Haifa, Israel

来源：

JOURNAL OF PEDIATRICS | 2010年 / 156卷 / 02期

关键词：

LOW-BIRTH-WEIGHT; PREVENT NECROTIZING ENTEROCOLITIS; PREBIOTIC OLIGOSACCHARIDES; DIETETIC PRODUCTS; ESPGHAN COMMITTEE; PRETERM INFANTS; PROBIOTICS; MICROFLORA; FORMULA; COLONIZATION;

D O I：

10.1016/j.jpeds.2009.09.006

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective To assess the safety and prebiotic effects of lactulose in preterm infants. Study design This was a prospective, double-blinded, placebo-controlled, single-center study in 23- to 34-weeks premature infants. The study group received 1% lactulose, and control infants received 1% dextrose in all feeds (human milk or formula). Results Twenty-eight infants participated (15 lactulose, 13 placebo). Small doses of lactulose appeared to be safe and did not cause diarrhea. Premature infants on lactulose had more Lactobacilli-positive stool cultures that appeared earlier with larger number of colonies. The lactulose group tended to have less intolerance to enteral feedings, to reach full oral feeds earlier, and to be discharged home earlier. They also tended to have fewer episodes of late-onset sepsis, lower Bell stage necrotizing enterocolitis, and their nutritional laboratory indices were better, especially calcium and total protein. Conclusions This pilot study supports the safety of supplementing preterm infants' feeds with low doses of lactulose. It also demonstrated trends that may suggest positive prebiotic effects. (J Pediatr 2010;156:209-14).

引用

页码：209 / 214

页数：6

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