High-Contrast In Vivo Visualization of Microvessels Using Novel FeCo/GC Magnetic Nanocrystals

被引：33

作者：

Lee, Jin Hyung ^{[2
]}

Sherlock, Sarah P. ^{[1
]}

Terashima, Masahiro ^{[5
]}

Kosuge, Hisanori ^{[5
]}

Suzuki, Yoriyasu ^{[5
]}

Goodwin, Andrew ^{[1
]}

Robinson, Joshua ^{[1
]}

Seo, Won Seok ^{[1
,3
]}

Liu, Zhuang ^{[1
]}

Luong, Richard ^{[4
]}

McConnell, Michael V. ^{[2
,5
]}

Nishimura, Dwight G. ^{[2
]}

Dai, Hongjie ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA

[3] Sogang Univ, Dept Chem, Inorgan & Biomat Ctr BK21, Seoul 121742, South Korea

[4] Stanford Univ, Sch Med, Dept Comparat Med, Stanford, CA 94305 USA

[5] Stanford Univ, Div Cardiovasc Med, Stanford, CA 94305 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 2009年 / 62卷 / 06期

关键词：

FeCo/GC; nanocrystal; contrast agent; high-resolution angiography; PAD; MR-ANGIOGRAPHY; AGENTS; ANGIOGENESIS; NANOPARTICLES; GROWTH; MODEL;

D O I：

10.1002/mrm.22132

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

FeCo-graphitic carbon shell nanocrystals are a novel MRI contrast agent with unprecedented high per-metal-atom-basis relaxivity (r(1) = 97 mM(-1) sec(-1), r(2) = 400 mM(-1) sec(-1)) and multifunctional capabilities. While the conventional gadolinium-based contrast-enhanced angiographic magnetic MRI has proven useful for diagnosis of vascular diseases, its short circulation time and relatively low sensitivity render high-resolution MRI of morphologically small vascular structures such as those involved in collateral, arteriogenic, and angiogenic vessel formation challenging. Here, by combining FeCo-graphitic carbon shell nanocrystals with high-resolution MRI technique, we demonstrate that such microvessels down to similar to 100 mu m can be monitored in high contrast and noninvasively using a conventional 1.5-T clinical MRI system, achieving a diagnostic imaging standard approximating that of the more invasive X-ray angiography. Preliminary in vitro and in vivo toxicity study results also show no sign of toxicity. Magn Reson Med 62:1497-1509, 2009. (C) 2009 Wiley-Liss, Inc.

引用

页码：1497 / 1509

页数：13

共 43 条

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