YY1-Induced Upregulation of Long Noncoding RNA ARAP1-AS1 Promotes Cell Migration and Invasion in Colorectal Cancer Through the Wnt/β-Catenin Signaling Pathway

被引：43

作者：

Ye, Yaqun ^{[1
]}

Gu, Binbin ^{[2
]}

Wang, Yi ^{[2
]}

Shen, Sudan ^{[2
]}

Huang, Wei ^{[2
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 1, Operating Room, Wenzhou, Zhejiang, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 1, Nutr Dept, Wenzhou 325000, Zhejiang, Peoples R China

来源：

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | 2019年 / 34卷 / 08期

关键词：

colorectal cancer; lncRNA ARAP1-AS1; migration; Wnt; beta-catenin signaling pathway; YY1; PROGRESSION; METASTASIS; STATISTICS; CARCINOMA; COLON;

D O I：

10.1089/cbr.2018.2745

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: It has been reported that long noncoding RNAs (lncRNAs) are crucial regulators in progression of human cancers, including colorectal cancer (CRC). However, the function of lncRNA ARAP1 antisense RNA 1 (ARAP1-AS1) in CRC remains unclear. Aim: The aim of this study was to investigate the function and molecular mechanism of lncRNA ARAP1-AS1 in CRC. Results: ARAP1-AS1 was highly expressed in CRC tissues and cell lines. ARAP1-AS1 knockdown suppressed cell migration, invasion, and epithelial-mesenchymal transition (EMT). YY1 transcription factor (YY1) enhanced the transcription activity of ARAP1-AS1. The YY1/ARAP1-AS1 axis promoted CRC cell migration and invasion. YY1/ARAP1-AS1 could regulate the Wnt/beta-catenin signaling pathway. Conclusions: This study revealed that YY1-induced upregulation of ARAP1-AS1 promoted cell migration, invasion, and EMT process in CRC through the Wnt/beta-catenin signaling pathway.

引用

页码：519 / 528

页数：10

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