SELF-ASSEMBLED TETHERED BIMOLECULAR LIPID MEMBRANES

被引：21

作者：

Sinner, Eva-Kathrin ^{[1
,4
]}

Ritz, Sandra ^{[1
]}

Naumann, Renate ^{[1
,2
]}

Schiller, Stefan ^{[3
]}

Knoll, Wolfgang ^{[2
,4
]}

机构：

[1] Max Planck Inst Polymer Res, Mainz, Germany

[2] Austrian Inst Technol, Vienna, Austria

[3] Freiburg Inst Adv Studies, Freiburg, Germany

[4] Inst Mat Res & Engn, Singapore, Singapore

来源：

ADVANCES IN CLINICAL CHEMISTRY, VOL 49 | 2009年 / 49卷

关键词：

CYTOCHROME-C-OXIDASE; SURFACE-PLASMON; BETA-PROTEIN; IN-VITRO; BILAYER; RECONSTITUTION; THIOLIPIDS; ATTACHMENT; ALZHEIMER; TRANSPORT;

D O I：

10.1016/S0065-2423(09)49007-3

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This chapter describes some of the strategies developed in our group for designing, constructing and structurally and functionally characterizing tethered bimolecular lipid membranes (tBLM). We introduce this platform as a novel model membrane system that complements the existing ones, for example, Langmuir monolayers, vesicular liposomal dispersions and bimolecular ("black") lipid membranes. Moreover, it offers the additional advantage of allowing for studies of the Influence of membrane structure and order on the function of integral proteins, for example, on how the composition and organization of lipids in a mixed membrane influence the ion translocation activity of integral channel proteins.

引用

页码：159 / 179

页数：21

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