Effect of berberine on bone mineral density in SAMP6 as a senile osteoporosis model

被引：29

作者：

Li, HY

Miyahara, T

Tezuka, Y

Le Tran, Q

Seto, H

Kadota, S

机构：

[1] Toyama Med & Pharmaceut Univ, Inst Nat Med, Toyama 9300194, Japan

[2] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Toyama 9300194, Japan

[3] Toyama Med & Pharmaceut Univ, Fac Med, Toyama 9300194, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2003年 / 26卷 / 01期

关键词：

berberine; senescence accelerated mice P6 (SAMP6); bone mineral density (BMD); deoxypyridinoline (Dpd); pro-collagen type I carboxyterminal extension peptide (PICP);

D O I：

10.1248/bpb.26.110

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of berberine in senescence accelerated mice P6 (SAMP6) were investigated to learn whether the alkaloid affects bone mineral density (BMD). Oral administration of berberine (10 mg/kg/d) to male and female mice for 22 weeks resulted in an increase in BMD in both sexes. A decreased concentration of deoxypyridinoline (Dpd) in urine was only observed in female mice. There was no effect on body or tibia weight or on the concentration of procollagen type I carboxyterminal extension peptide (PICP) in serum.

引用

页码：110 / 111

页数：2

共 15 条

[1] Collagen cross-links. Synthesis of immunoreagents for development of assays for deoxypyridinoline, a marker for diagnosis of osteoporosis [J].