TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden

被引：69

作者：

Mayans, Sofia

Lackovic, Kurt

Lindgren, Petter

Ruikka, Karin

Agren, Asa

Eliasson, Mats

Holmberg, Dan ^{[1
]}

机构：

[1] Umea Univ, Div Med & Clin Genet, Dept Med Biosci, S-90185 Umea, Sweden

[2] Sundby Hosp, Dept Med, Lulea, Sweden

[3] Umea Univ, Dept Publ Hlth & Clin Sci, Umea, Sweden

来源：

EUROPEAN JOURNAL OF HUMAN GENETICS | 2007年 / 15卷 / 03期

基金：

瑞典研究理事会;

关键词：

association; diabetes; polymorphism; TCF7L2;

D O I：

10.1038/sj.ejhg.5201773

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A recent study found association of one microsatellite and five single nucleotide polymorphisms ( SNPs) in intron 3 of the TCF7L2 gene with type 2 diabetes (T2D) in the Icelandic, Danish and American populations. The aim of the present study was to investigate if those SNPs were associated to T2D in two (family- and population-based) cohorts from northern Sweden. We genotyped four of the associated SNPs in a case-control cohort consisting of 872 T2D cases and 857 controls matched with respect to age, sex and geographical origin and in a sample of 59 extended families ( 148 affected and 83 unaffected individuals). Here, we report replication of association between T2D and three SNPs in the case-control (rs7901695, P=0.003; rs7901346, P=0.00002; and rs12255372, P=0.000004) and two SNPs in the family- based ( rs7901695, P=0.01 and rs7901346, P=0.04) samples from northern Sweden. This replication strengthens the evidence for involvement of TCF7L2 in T2D.

引用

页码：342 / 346

页数：5

共 23 条

[1] A haplotype map of the human genome [J].

Altshuler, D ;

Brooks, LD ;

Chakravarti, A ;

Collins, FS ;

Daly, MJ ;

Donnelly, P ;

Gibbs, RA ;

Belmont, JW ;

Boudreau, A ;

Leal, SM ;

Hardenbol, P ;

Pasternak, S ;

Wheeler, DA ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Zeng, CQ ;

Gao, Y ;

Hu, HR ;

Hu, WT ;

Li, CH ;

Lin, W ;

Liu, SQ ;

Pan, H ;

Tang, XL ;

Wang, J ;

Wang, W ;

Yu, J ;

Zhang, B ;

Zhang, QR ;

Zhao, HB ;

Zhao, H ;

Zhou, J ;

Gabriel, SB ;

Barry, R ;

Blumenstiel, B ;

Camargo, A ;

Defelice, M ;

Faggart, M ;

Goyette, M ;

Gupta, S ;

Moore, J ;

Nguyen, H ;

Onofrio, RC ;

Parkin, M ;

Roy, J ;

Stahl, E ;

Winchester, E ;

Ziaugra, L ;

Shen, Y .

NATURE, 2005, 437 (7063) :1299-1320

[2] The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].

Altshuler, D ;

Hirschhorn, JN ;

Klannemark, M ;

Lindgren, CM ;

Vohl, MC ;

Nemesh, J ;

Lane, CR ;

Schaffner, SF ;

Bolk, S ;

Brewer, C ;

Tuomi, T ;

Gaudet, D ;

Hudson, TJ ;

Daly, M ;

Groop, L ;

Lander, ES .

NATURE GENETICS, 2000, 26 (01) :76-80

[3]

[Anonymous], [No title captured]

[4] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[5] TCF7L2 variation predicts hyperglycentia incidence in a French general population -: The Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study [J].

Cauchi, Stephane ;

Meyre, David ;

Choquet, Helene ;

Dina, Christian ;

Born, Catherine ;

Marre, Michel ;

Balkau, Beverley ;

Froguel, Philippe .

DIABETES, 2006, 55 (11) :3189-3192

[6] Transcription factor TCF7L2 genetic study in the French population -: Expression in human β-cells and adipose tissue and strong association with type 2 diabetes [J].

Cauchi, Stephane ;

Meyre, David ;

Dina, Christian ;

Choquet, Helene ;

Samson, Chantal ;

Gallina, Sophie ;

Balkau, Beverley ;

Charpentier, Guillaume ;

Pattou, Francois ;

Stetsyuk, Volodymyr ;

Scharfmann, Raphael ;

Staels, Bart ;

Fruhbeck, Gema ;

Froguel, Philippe .

DIABETES, 2006, 55 (10) :2903-2908

[7] A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission [J].

Clayton, D .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) :1170-1177

[8] Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish -: Replication and evidence for a role in both insulin secretion and insulin resistance [J].

Damcott, Coleen M. ;

Pollin, Toni I. ;

Reinhart, Laurie J. ;

Ott, Sandra H. ;

Shen, Haiqing ;

Silver, Kristi D. ;

Mitchell, Braxton D. ;

Shuldiner, Alan R. .

DIABETES, 2006, 55 (09) :2654-2659

[9] Linkage but not association of calpain-10 to type 2 diabetes replicated in northern Sweden [J].

Einarsdottir, Elisabet ;

Mayans, Sofia ;

Ruikka, Karin ;

Escher, Stefan A. ;

Lindgren, Petter ;

Agren, Asa ;

Eliasson, Mats ;

Holmberg, Dan .

DIABETES, 2006, 55 (06) :1879-1883

[10] A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians [J].

Elbein, SC ;

Hoffman, MD ;

Teng, K ;

Leppert, MF ;

Hasstedt, SJ .

DIABETES, 1999, 48 (05) :1175-1182

← 1 2 3 →