Clinical Pharmacokinetics and Pharmacodynamics of Eravacycline

被引：14
作者：
McCarthy, Matthew W. [1 ]
机构：
[1] Weill Cornell Med Coll, New York, NY 10065 USA
来源：
CLINICAL PHARMACOKINETICS | 2019年 / 58卷 / 09期
关键词：
KLEBSIELLA-PNEUMONIAE; RESISTANCE; FLUOROCYCLINE; ENTEROBACTERIACEAE; EMERGENCE; SAFETY; TP-434;
D O I：
10.1007/s40262-019-00767-z
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
On 27 August, 2018, the US Food and Drug Administration approved eravacycline, a fluorocycline antimicrobial agent within the tetracycline class of antibacterial drugs, for the treatment of complicated intra-abdominal infections in patients aged 18years and older. This decision was based on substantial clinical and pre-clinical data, including rigorous pharmacokinetic and pharmacodynamic work. This paper examines the in-vivo pharmacokinetic/pharmacodynamic work that led to the approval of eravacycline and explores how this important new antibiotic may be used to treat aggressive multidrug-resistant infections in the years ahead.
引用
收藏
页码：1149 / 1153
页数：5
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