Specific biological responses following dextran-coated ultra-small superparamagnetic particles of iron oxides administration

被引：0
|
作者：
Jiang, Zhiming [1 ]
Lin, Chenghong [1 ]
Liu, Huili [2 ]
Feng, Jianghua [1 ]
Zheng, Zhenyao [1 ]
Cai, Shuhui [1 ]
机构：
[1] Xiamen Univ, Fujian Prov Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Fujian, Peoples R China
[2] Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China
来源：
NANOMEDICINE | 2019年 / 14卷 / 11期
基金：
中国国家自然科学基金;
关键词：
biological response; contrast agent; metabolomic analysis; NMR spectroscopy; nuclear magnetic resonance; ultra-small superparamagnetic particles of iron oxides; USPIO; LIVER-CIRRHOSIS; NANOPARTICLES; PHENYLALANINE; TAURINE; USPIO; METABOLISM; DISEASE; RATS;
D O I：
10.2217/nnm-2018-0433
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: The potential bio-related risks of dextran-coated ultra-small superparamagnetic particles of iron oxides (D-USPIO) were assessed. Materials & methods: Metabolic responses of D-USPIO in BALB/C mice were obtained using H-1-NMR-based metabolomic strategy combined with the traditional biochemical assay. Results: The metabolomic analyses of biological fluids (plasma and urine) and organs (liver, kidney and spleen) indicated that the disturbance, impairment and recovery of the physiological functions were related to the metabolic response to D-USPIO. The correlations between the biofluids and tissue metabolomes described the specific metabolic information of D-USPIO on their in vivo transportation, absorption, biodistribution and excretion. Conclusion: Metabolomic analysis provides preliminary validation for the use of D-USPIO in clinical medicine, and the results help to understand the potential adverse effects of the similar bio-nanomaterials further serve to their synthesis optimization and biocompatibility improvement.
引用
收藏
页码：1371 / 1386
页数：16
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