BIGINELLI REACTION VIA BIS-UREIDE INTERMEDIATE IN LOW MELTING MIXTURE

被引：0

作者：

Mahajan, Hitesh ^{[1
]}

Jamwal, Babita ^{[1
]}

Paul, Satya ^{[1
]}

机构：

[1] Univ Jammu, Dept Chem, Jammu 180006, Jammu & Kashmir, India

来源：

REVUE ROUMAINE DE CHIMIE | 2019年 / 64卷 / 07期

关键词：

Biginelli reaction; reaction mechanism; bis-ureide intermediate; one-pot synthesis; low melting mixture; ONE-POT SYNTHESIS; MULTICOMPONENT REACTIONS; ORGANIC-SYNTHESIS; 3-COMPONENT; CATALYST; EFFICIENT; HANTZSCH; SOLVENTS;

D O I：

10.33224/rrch.2019.64.7.05

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper deals with the study of mechanism of the Biginelli reaction using low melting mixture as solvent and catalyst. The catalytic effect of low melting mixture and the reaction mechanism is discussed on the basis of nuclear magnetic resonance (NMR) and mass spectrometry (ESI-MS). All experimental measurements point to a mechanism involving bis-ureide derivative as a key intermediate, formed by the reaction of benzaldehyde and urea in low melting mixture.

引用

页码：585 / 593

页数：9

共 3 条

[1] Bis[(L)prolinato-N,O]Zn-water: A green catalytic system for the synthesis of 3,4-dihydropyrimidin-2 (1H)-ones via the Biginelli reaction
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[2] Studies on the Biginelli reaction : Synthesis of 3,4-dihydropyrimidin-2(1H)-thiones via arylidene intermediate and one pot reaction
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[3] 1, 1′-Sulfinyldiethylammonium Bis (Hydrogen Sulfate) as a Recyclable Dicationic Ionic Liquid Catalyst for the Efficient Solvent-free Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones via Biginelli Reaction
Ehsani-Nasab, Zainab
Ezabadi, Ali
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING, 2020, 23 (02) : 157 - 167

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