Novel Strategies for Spinal Cord Regeneration

被引：29
作者：
Costachescu, Bogdan [1 ,2 ]
Niculescu, Adelina-Gabriela
Dabija, Marius Gabriel [1 ,2 ]
Teleanu, Raluca Ioana [4 ,5 ]
Grumezescu, Alexandru Mihai [3 ,6 ,7 ]
Eva, Lucian [2 ]
机构：
[1] Gr T Popa Univ Med & Pharm, Iasi 700115, Romania
[2] Prof Dr N Oblu Emergency Clin Hosp, Iasi 700309, Romania
[3] Politeh Univ Bucharest, Fac Appl Chem & Mat Sci, Dept Sci & Engn Oxide Mat & Nanomat, Bucharest 011061, Romania
[4] Dr Victor Gomoiu Childrens Hosp, Dept Pediat Neurol, Bucharest 022102, Romania
[5] Carol Davila Univ Med & Pharm, Bucharest 020021, Romania
[6] Univ Bucharest, Univ Bucharest ICUB, Res Inst, Bucharest 050657, Romania
[7] Acad Romanian Scientists, Ilfov 3, Bucharest 050044, Romania
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 09期
关键词：
spinal cord injury; delivery nanosystems; biomaterial scaffolds; stem cells; tissue engineering; spinal cord regeneration; MESENCHYMAL STEM-CELLS; DRUG-DELIVERY SYSTEM; FUNCTIONAL RECOVERY; NEURONAL DIFFERENTIATION; AXONAL REGENERATION; GOLD NANOPARTICLES; INJURY; SCAFFOLDS; TISSUE; PROMOTES;
D O I：
10.3390/ijms23094552
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A spinal cord injury (SCI) is one of the most devastating lesions, as it can damage the continuity and conductivity of the central nervous system, resulting in complex pathophysiology. Encouraged by the advances in nanotechnology, stem cell biology, and materials science, researchers have proposed various interdisciplinary approaches for spinal cord regeneration. In this respect, the present review aims to explore the most recent developments in SCI treatment and spinal cord repair. Specifically, it briefly describes the characteristics of SCIs, followed by an extensive discussion on newly developed nanocarriers (e.g., metal-based, polymer-based, liposomes) for spinal cord delivery, relevant biomolecules (e.g., growth factors, exosomes) for SCI treatment, innovative cell therapies, and novel natural and synthetic biomaterial scaffolds for spinal cord regeneration.
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页数：22
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