Novel Strategies for Spinal Cord Regeneration

被引：29

作者：

Costachescu, Bogdan ^{[1
,2
]}

Niculescu, Adelina-Gabriela

Dabija, Marius Gabriel ^{[1
,2
]}

Teleanu, Raluca Ioana ^{[4
,5
]}

Grumezescu, Alexandru Mihai ^{[3
,6
,7
]}

Eva, Lucian ^{[2
]}

机构：

[1] Gr T Popa Univ Med & Pharm, Iasi 700115, Romania

[2] Prof Dr N Oblu Emergency Clin Hosp, Iasi 700309, Romania

[3] Politeh Univ Bucharest, Fac Appl Chem & Mat Sci, Dept Sci & Engn Oxide Mat & Nanomat, Bucharest 011061, Romania

[4] Dr Victor Gomoiu Childrens Hosp, Dept Pediat Neurol, Bucharest 022102, Romania

[5] Carol Davila Univ Med & Pharm, Bucharest 020021, Romania

[6] Univ Bucharest, Univ Bucharest ICUB, Res Inst, Bucharest 050657, Romania

[7] Acad Romanian Scientists, Ilfov 3, Bucharest 050044, Romania

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 09期

关键词：

spinal cord injury; delivery nanosystems; biomaterial scaffolds; stem cells; tissue engineering; spinal cord regeneration; MESENCHYMAL STEM-CELLS; DRUG-DELIVERY SYSTEM; FUNCTIONAL RECOVERY; NEURONAL DIFFERENTIATION; AXONAL REGENERATION; GOLD NANOPARTICLES; INJURY; SCAFFOLDS; TISSUE; PROMOTES;

D O I：

10.3390/ijms23094552

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A spinal cord injury (SCI) is one of the most devastating lesions, as it can damage the continuity and conductivity of the central nervous system, resulting in complex pathophysiology. Encouraged by the advances in nanotechnology, stem cell biology, and materials science, researchers have proposed various interdisciplinary approaches for spinal cord regeneration. In this respect, the present review aims to explore the most recent developments in SCI treatment and spinal cord repair. Specifically, it briefly describes the characteristics of SCIs, followed by an extensive discussion on newly developed nanocarriers (e.g., metal-based, polymer-based, liposomes) for spinal cord delivery, relevant biomolecules (e.g., growth factors, exosomes) for SCI treatment, innovative cell therapies, and novel natural and synthetic biomaterial scaffolds for spinal cord regeneration.

引用

页数：22

共 124 条

[1] Effects of paired stimulation with specific waveforms on cortical and spinal plasticity in subjects with a chronic spinal cord injury [J].

Adeel, Muhammad ;

Lai, Chien -Hung ;

Lin, Bor-Shing ;

Chan, Wing P. ;

Liou, Jian-Chiun ;

Wu, Chun-Wei ;

Peng, Chih-Wei .

JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2022, 121 (10) :2044-2056

[2] Development of a Bioactive Scaffold based on NGF Containing PCL/Chitosan Nanofibers for Nerve Regeneration [J].

Afrash, Hamed ;

Nazeri, Niloofar ;

Davoudi, Parivash ;

FaridiMajidi, Reza ;

Ghanbari, Hossein .

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2021, 11 (05) :12606-12617

[3] Gold nanoparticle and polyethylene glycol in neural regeneration in the treatment of neurodegenerative diseases [J].

Aghaie, Tayebe ;

Jazayeri, Mir Hadi ;

Manian, Mostafa ;

Khani, Leila ;

Erfani, Marjan ;

Rezayi, Majid ;

Ferns, Gordon A. ;

Avan, Amir .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (03) :2749-2755

[4] Nanoparticles with antioxidant enzymes protect injured spinal cord from neuronal cell apoptosis by attenuating mitochondrial dysfunction [J].

Andrabi, Syed Suhail ;

Yang, Jun ;

Gao, Yue ;

Kuang, Youzhi ;

Labhasetwar, Vinod .

JOURNAL OF CONTROLLED RELEASE, 2020, 317 :300-311

[5]

Ashammakhi N, 2019, TISSUE ENG PART B-RE, V25, P471, DOI [10.1089/ten.teb.2019.0182, 10.1089/ten.TEB.2019.0182]

[6] ChABC-loaded PLGA nanoparticles: A comprehensive study on biocompatibility, functional recovery, and axonal regeneration in animal model of spinal cord injury [J].

Azizi, Monireh ;

Farahmandghavi, Farhid ;

Joghataei, Mohammad Taghi ;

Zandi, Mojgan ;

Imani, Mohammad ;

Bakhtiari, Mehrdad ;

Omidian, Hamid .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 577

[7] PCL/gelatin nanofibrous scaffolds with human endometrial stem cells/Schwann cells facilitate axon regeneration in spinal cord injury [J].

Babaloo, Hamideh ;

Ebrahimi-Barough, Somayeh ;

Derakhshan, Mohammad Ali ;

Yazdankhah, Meysam ;

Lotfibakhshaiesh, Nasrin ;

Soleimani, Masoud ;

Joghataei, Mohammad-Taghi ;

Ai, Jafar .

JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (07) :11060-11069

[8] Role of Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Cardiac Tissue and Improvement of Cardiac Function: a Narrative Review [J].

Bahardoust, Mnasour ;

Baghoi-Hosseinabadi, Zahra .

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2021, 11 (01) :8446-8456

[9] Update on the treatment of spinal cord injury [J].

Baptiste, Darryl C. ;

Fehlings, Michael G. .

NEUROTRAUMA: NEW INSIGHTS INTO PATHOLOGY AND TREATMENT, 2007, 161 :217-233

[10] Mapping molecular electrostatic potential for heme interacting with nano metal oxides [J].

Bayoumy, Ahmed M. ;

Elhaes, Hanan ;

Osman, Osama ;

Hussein, Tarek ;

Ibrahim, Medhat A. .

BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2020, 10 (02) :5091-5095

← 1 2 3 4 5 6 7 8 9 10 →