Incidence and Comorbidity of Dementia with Lewy Bodies: A Population-Based Cohort Study

被引:17
作者
Yang, Sheng-Kung [1 ]
Chen, Weishan [2 ,3 ]
Su, Chun-Hsien [4 ]
Liu, Chung-Hsiang [5 ]
机构
[1] Chang Bing Show Chwan Mem Hosp, Dept Neurol, Changhua, Changhua County, Taiwan
[2] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan
[3] China Med Univ, Coll Med, Taichung, Taiwan
[4] Chinese Culture Univ, Coll Educ, Dept Exercise & Hlth Promot, Taipei, Taiwan
[5] China Med Univ Hosp, Dept Neurol, Taichung, Taiwan
关键词
ALZHEIMERS-DISEASE; DIAGNOSIS; CHOLESTEROL; PREVALENCE; DLB; CONSORTIUM; PATHOLOGY; BRAIN;
D O I
10.1155/2018/7631951
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background and Aims. Dementia with Lewy bodies (DLB) is the third most common form of dementia. Epidemiological studies of DLB in Taiwan are scarce. In this study, we estimated the incidence of DLB and comorbidity in the population of Taiwan. Methods. Data were obtained from the Taiwan National Health Insurance Research Database (NHIRD). DLB patients between 2000 and 2013 were enrolled in assessments of incidence and comorbidity. Results. The incidence of DLB was shown to be 7.10 per 100,000 person-years (95% CI = 6.63-7.59), which increased with age. The average age at diagnosis was 76.3, and this was higher for males than for females. The comorbidity rates of hypertension and hyperlipidemia in DLB patients were higher in females than in males. Conclusions. Epidemiologic data from large-scale retrospective studies is crucial to the prevention of DLB.
引用
收藏
页数:6
相关论文
共 27 条
[1]   Comorbidity and dementia: A nationwide survey in Taiwan [J].
Chen, Ting-Bin ;
Yiao, Szu-Yu ;
Sun, Yu ;
Lee, Huey-Jane ;
Yang, Shu-Chien ;
Chiu, Ming-Jang ;
Chen, Ta-Fu ;
Lin, Ker-Neng ;
Tang, Li-Yu ;
Lin, Chung-Chih ;
Wang, Pei-Ning .
PLOS ONE, 2017, 12 (04)
[2]   Drug therapy - Alzheimer's disease [J].
Cummings, JL .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (01) :56-67
[3]   Comorbidity profile in dementia with Lewy bodies versus Alzheimer's disease: a linkage study between the Swedish Dementia Registry and the Swedish National Patient Registry [J].
Fereshtehnejad, Seyed-Mohammad ;
Damangir, Soheil ;
Cermakova, Pavla ;
Aarsland, Dag ;
Eriksdotter, Maria ;
Religa, Dorota .
ALZHEIMERS RESEARCH & THERAPY, 2014, 6 (05)
[4]   Hypertension is Related to the Microstructure of the Corpus Callosum: The RUN DMC Study [J].
Gons, Rob A. R. ;
van Oudheusden, Lucas J. B. ;
de Laat, Karlijn F. ;
van Norden, Anouk G. W. ;
van Uden, Inge W. M. ;
Norris, David G. ;
Zwiers, Marcel P. ;
van Dijk, Ewoud ;
de Leeuw, Frank-Erik .
JOURNAL OF ALZHEIMERS DISEASE, 2012, 32 (03) :623-631
[5]   Neuropathology underlying clinical variability in patients with synucleinopathies [J].
Halliday, Glenda M. ;
Holton, Janice L. ;
Revesz, Tamas ;
Dickson, Dennis W. .
ACTA NEUROPATHOLOGICA, 2011, 122 (02) :187-204
[6]   The Prevalence and Incidence of Dementia with Lewy Bodies: a Systematic Review [J].
Hogan, David B. ;
Fiest, Kirsten M. ;
Roberts, Jodie I. ;
Maxwell, Colleen J. ;
Dykeman, Jonathan ;
Pringsheim, Tamara ;
Steeves, Thomas ;
Smith, Eric E. ;
Pearson, Dawn ;
Jette, Nathalie .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2016, 43 :S83-S95
[7]  
Holdorff Bernd, 2002, J Hist Neurosci, V11, P19, DOI 10.1076/jhin.11.1.19.9106
[8]  
Jones SAV, 2014, PSYCHOL MED, V44, P673, DOI 10.1017/S0033291713000494
[9]   DLB and PDD boundary issues - Diagnosis, treatment, molecular pathology, and biomarkers [J].
Lippa, C. F. ;
Duda, J. E. ;
Grossman, M. ;
Hurtig, H. I. ;
Aarsland, D. ;
Boeve, B. F. ;
Brooks, D. J. ;
Dickson, D. W. ;
Dubois, B. ;
Emre, M. ;
Fahn, S. ;
Farmer, J. M. ;
Galasko, D. ;
Galvin, J. E. ;
Goetz, C. G. ;
Growdon, J. H. ;
Gwinn-Hardy, K. A. ;
Hardy, J. ;
Heutink, P. ;
Iwatsubo, T. ;
Kosaka, K. ;
Lee, V. M. -Y. ;
Leverenz, J. B. ;
Masliah, E. ;
McKeith, I. G. ;
Nussbaum, R. L. ;
Olanow, C. W. ;
Ravina, B. M. ;
Singleton, A. B. ;
Tanner, C. M. ;
Trojanowski, J. Q. ;
Wszolek, Z. K. .
NEUROLOGY, 2007, 68 (11) :812-819
[10]   Research evaluation and prospective diagnosis of dementia with Lewy bodies [J].
Lopez, OL ;
Becher, JT ;
Kaufer, DI ;
Hamilton, RL ;
Sweet, RA ;
Klunk, W ;
DeKosky, ST .
ARCHIVES OF NEUROLOGY, 2002, 59 (01) :43-46