Suzuki-Miyaura Coupling of Aryl Carbamates, Carbonates, and Sulfamates

被引:274
|
作者
Quasdorf, Kyle W. [1 ]
Riener, Michelle [1 ]
Petrova, Krastina V. [1 ]
Garg, Neil K. [1 ]
机构
[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
关键词
NICKEL/MAGNESIUM BIMETALLIC COOPERATION; DIRECTED ORTHO-METALATION; GRIGNARD-REAGENTS; POLYSUBSTITUTED AROMATICS; BORONIC ACIDS; ACTIVATION; BOND; CARBOXYLATES; FLURBIPROFEN; FLUORIDES;
D O I
10.1021/ja906477r
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Chemical Equation Presented) The first Suzuki-Miyaura cross-couplings of carbamates, carbonates, and sulfamates is described. The method provides a powerful means of using simple derivatives of phenol as precursors to polysubstituted aromatic compounds, as exemplified by a concise synthesis of the anti-inflammatory drug flurbiprofen. © 2009 American Chemical Society.
引用
收藏
页码:17748 / 17749
页数:2
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