Managing hot flushes in men after prostate cancer-A systematic review

被引:36
作者
Frisk, Jessica [1 ]
机构
[1] Linkoping Univ, Fac Hlth Sci, Dept Clin & Expt Med, Div Obstet & Gynaecol, S-58183 Linkoping, Sweden
关键词
Prostate cancer; Androgen deprivation therapy; Vasomotor symptoms; Hot flushes; Treatment; GENE-RELATED PEPTIDE; ANDROGEN-DEPRIVATION THERAPY; QUALITY-OF-LIFE; VASOMOTOR SYMPTOMS; PILOT EVALUATION; LUTEINIZING-HORMONE; MEGESTROL-ACETATE; POSTMENOPAUSAL WOMEN; MENOPAUSAL SYMPTOMS; CYPROTERONE-ACETATE;
D O I
10.1016/j.maturitas.2009.10.017
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Context and objective: The aim of this study was to describe hot flushes in men with prostate cancer, and their treatment methods. Method: A systematic review was conducted of the literature indexed between 1966 and 2009 on the MEDLINE, the ISI Web of Knowledge, Cinahl and PsycINFO. Of 252 articles identified, 32 were selected for consideration of their complete texts, of which five were subject to detailed analysis. Results: Diethylstilbestrol, megestrol acetate and cyproterone acetate have the strongest effect, giving a 75% or larger decrease of the number of hot flushes, but they may have severe or bothersome side-effects. Gabapentin has an uncertain effect. Clonidine is not proven effective for hot flushes. Long-term effects were not evaluated in any of the studies. SSRI/SNRI and acupuncture may have a moderate effect on hot flushes but are not proven in any RCTs. Conclusion: Hot flushes are common and bothersome symptoms in men with prostate cancer and those taking anti-androgen treatment, and reduce quality of life. Few treatments are available and some are avoided for these patients. Additional prospective treatment studies are needed, with long-term follow-up, in order to evaluate the effects and risks of treatments. Treatments with few or no severe side-effects should be prioritised in future investigations. Experimental studies are also needed to elucidate the mechanism behind hot flushes in men and to suggest routes for the development of new treatments. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:15 / 22
页数:8
相关论文
共 63 条
  • [1] Acupuncture in managing menopausal symptoms: hope or mirage?
    Alfhaily, F.
    Ewies, A. A. A.
    [J]. CLIMACTERIC, 2007, 10 (05) : 371 - 380
  • [2] DIETHYLSTILBESTROL IN TREATMENT OF POSTORCHIECTOMY VASOMOTOR SYMPTOMS AND ITS RELATIONSHIP WITH SERUM FOLLICLE-STIMULATING-HORMONE, LUTEINIZING-HORMONE, AND TESTOSTERONE
    ATALA, A
    AMIN, M
    HARTY, JI
    [J]. UROLOGY, 1992, 39 (02) : 108 - 110
  • [3] Depomedroxyprogesterone acetate for hot flashes
    Barton, D
    Loprinzi, C
    Quella, S
    Sloan, J
    Pruthi, S
    Novotny, P
    [J]. JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2002, 24 (06) : 603 - 607
  • [4] Effect of high-dose isoflavones on cognition, quality of life, androgens, and lipoprotein in post-menopausal women
    Basaria, S.
    Wisniewski, A.
    Dupree, K.
    Bruno, T.
    Song, M. -Y.
    Yao, F.
    Ojumu, A.
    John, M.
    Dobs, A. S.
    [J]. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2009, 32 (02) : 150 - 155
  • [5] USE OF CLONIDINE TO TREAT HOT FLASHES SECONDARY TO LEUPROLIDE OR GOSERELIN
    BRESSLER, LR
    MURPHY, CM
    SHEVRIN, DH
    WARREN, RF
    [J]. ANNALS OF PHARMACOTHERAPY, 1993, 27 (02) : 182 - 185
  • [6] Minimal decrease in hot flashes desired by postmenopausal women in family practice
    Butt, Debra A.
    Deng, Linda Y. R.
    Lewis, Jacqueline E.
    Lock, Michael
    [J]. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 2007, 14 (02): : 203 - 207
  • [7] Cabot A T, 1896, Ann Surg, V24, P265, DOI 10.1097/00000658-189607000-00036
  • [8] 'Hot flush', an unpleasant symptom accompanying antiandrogen therapy of prostatic cancer and its treatment by cyproterone acetate
    Cervenakov I.
    Kopecny M.
    Jancar M.
    Chovan D.
    Mal'a M.
    [J]. International Urology and Nephrology, 2000, 32 (1) : 77 - 79
  • [9] FLUSHING - LONG-TERM SIDE-EFFECT OF ORCHIECTOMY IN TREATMENT OF PROSTATIC-CARCINOMA
    CHARIG, CR
    RUNDLE, JS
    [J]. UROLOGY, 1989, 33 (03) : 175 - 178
  • [10] Menopausal hot flash and calciotonin gene-related peptide; effect of Keishi-bukuryo-gan, a kampo medicine, related to plasma calciotonin gene-related peptide level
    Chen, JT
    Shiraki, M
    [J]. MATURITAS, 2003, 45 (03) : 199 - 204