Biodistribution of anti-diabetic Zn(II) complexes in human serum and in vitro protein-binding studies by means of CZE-ICP-MS

被引：21

作者：

Bytzek, Anna K. ^{[1
]}

Enyedy, Eva A. ^{[2
]}

Kiss, Tamas ^{[2
]}

Keppler, Bernhard K. ^{[1
]}

Hartinger, Christian G. ^{[1
]}

机构：

[1] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

[2] Univ Szeged, Dept Inorgan & Analyt Chem, Szeged, Hungary

来源：

ELECTROPHORESIS | 2009年 / 30卷 / 23期

基金：

奥地利科学基金会;

关键词：

Anti-diabetic Zn(II) complexes; CE; ICP-MS; Protein Interactions; Speciation in blood serum; ANTICANCER METALLODRUG RESEARCH; MIMETIC ZINC(II) COMPLEXES; CAPILLARY-ELECTROPHORESIS; FUTURE-DIRECTIONS; HUMAN ALBUMIN; BOUND ZINC; PHASE-I; ALPHA-2-MACROGLOBULIN; TRANSFERRIN; VANADIUM;

D O I：

10.1002/elps.200900212

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Application of modem analytical technology for studying the fate of metallodrugs after administration to the blood is of utmost importance for drug development Zn(II) compounds are under development as insulin-enhancing drugs with potential use in the treatment of diabetes. in comparison to the well-established vanadium compounds, especially the lower risk of adverse effects due to the essentiality of the element in biological processes is advantageous. Herein, CZE-ICP-MS studies on the interaction of Zn(II)-maltolato, -2-picolinato and -2,6-dipicolinato complexes with human serum proteins are discussed and modeling calculations were confirmed by experimental results. Studies with human serum reveal preference for HSA over other less abundant proteins and serum components.

引用

页码：4075 / 4082

页数：8

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