Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications

被引：53

作者：

Jaeger, Eliezer ^{[1
]}

Hoecherl, Anita ^{[1
]}

Janouskova, Olga ^{[1
]}

Jaeger, Alessandro ^{[1
]}

Hruby, Martin ^{[1
]}

Konefal, Rafal ^{[1
]}

Netopilik, Milos ^{[1
]}

Panek, Jiri ^{[1
]}

Slouf, Miroslav ^{[1
]}

Ulbrich, Karel ^{[1
]}

Stepanek, Petr ^{[1
]}

机构：

[1] Acad Sci Czech Republic, Inst Macromol Chem, Vvi, Heyrovsky Sq 2, CR-16206 Prague 6, Czech Republic

来源：

NANOSCALE | 2016年 / 8卷 / 13期

关键词：

HYDROGEN-PEROXIDE; OXIDATIVE STRESS; CANCER-CELLS; TRIGGERED RELEASE; DUAL ROLE; KAPPA-B; INFLAMMATION; MICELLES; METABOLISM; ACTIVATION;

D O I：

10.1039/c6nr00791k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new drug-delivery system of polymer nanoparticles (NPs) bearing pinacol-type boronic ester and alkyne moieties displaying triggered self-immolative polymer degradation in the presence of reactive oxygen species (ROS) with the capability of cellular imaging is presented. The NPs specifically release their drug cargo under concentrations of ROS that are commonly found in the intracellular environment of certain tumors and of inflamed tissues and exhibit significant cytotoxicity to cancer cells compared to their non-ROS-responsive counterparts.

引用

页码：6958 / 6963

页数：6

共 42 条

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