Modern approaches towards the synthesis of geminal difluoroalkyl groups

被引：65

作者：

Carvalho, Dayanne R. ^{[1
]}

Christian, Alec H. ^{[1
]}

机构：

[1] Merck & Co Inc, Discovery Chem, 33 Ave Louis, Boston, MA 02115 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 05期

关键词：

We thank the future talent program at Merck & Co; Inc; Kenilworth; NJ; USA; for supporting D. R. C. for a summer internship. We thank Dr Duane DeMong; Dr Umar Faruk Mansoor; Dr Katrina Mennie; Dr Andrew Musacchio; and Dr Kelsey Poremba for edits and revisions to the manuscript;

D O I：

10.1039/d0ob02374d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review will cover the importance of and most recent approaches toward geminal difluoroalkyl groups. Transition metal-mediated, photochemical, organocatalytic, and other methods as well as their mechanistic implications will be discussed, with special emphasis on applications to biologically-relevant compounds.

引用

页码：947 / 964

页数：18

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