Bi(OTf)3-Mediated (4+1) Annulation of α-Sulfonyl o-Hydroxyacetophenones with α-Hydroxy Arylketones to Access Sulfonyl 2-Aroylbenzofurans

被引：20

作者：

Chang, Meng-Yang ^{[1
,2
]}

Chen, Kuan-Ting ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807, Taiwan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2021年 / 363卷 / 10期

关键词：

2-Aroylbenzofurans; Double Cyclocondensation; o-Hydroxyacetophenones; alpha-Hydroxy Arylketones; (4+1) Annulation;

D O I：

10.1002/adsc.202100143

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this paper, a high-yield, facile route for the scalable synthesis of sulfonyl 2-aroylbenzofurans via a Bi(OTf)(3)-mediated intermolecular double cyclocondensation of alpha-sulfonyl o-hydroxyacetophenones with substituted alpha-hydroxy arylketones under mild open-vessel reaction conditions is described. In the overall reaction, water is generated as the only byproduct. Various metal triflate-promoted reactions and conditions are investigated for the efficient one-pot (4 + 1) annulation reaction.

引用

页码：2594 / 2609

页数：16

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