Building ubiquitin chains: E2 enzymes at work

被引：740

作者：

Ye, Yihong ^{[1
]}

Rape, Michael ^{[2
]}

机构：

[1] NIDDK, Mol Biol Lab, Natl Inst Hlth, Bethesda, MD 20892 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2009年 / 10卷 / 11期

关键词：

ANAPHASE-PROMOTING COMPLEX; KAPPA-B ACTIVATION; CONJUGATING ENZYME; POLYUBIQUITIN CHAINS; IN-VITRO; DNA-REPAIR; YEAST RAD6; BRCA1/BARD1; HETERODIMER; MOLECULAR DETERMINANTS; ALLOSTERIC ACTIVATION;

D O I：

10.1038/nrm2780

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The modification of proteins with ubiquitin chains can change their localization, activity and/or stability. Although ubiquitylation requires the concerted action of ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s), it is the E2s that have recently emerged as key mediators of chain assembly. These enzymes are able to govern the switch from ubiquitin chain initiation to elongation, regulate the processivity of chain formation and establish the topology of assembled chains, thereby determining the consequences of ubiquitylation for the modified proteins.

引用

页码：755 / 764

页数：10

共 95 条

[11] The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain,, RING finger, and an E2-binding site
Chen, B
Mariano, J
Tsai, YC
Chan, AH
Cohen, M
Weissman, AM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (02) : 341 - 346
[12] CHEN ZJ, 1990, J BIOL CHEM, V265, P21835
[13] Ubiquitin signalling in the NF-κB pathway
Chen, ZJJ
[J]. NATURE CELL BIOLOGY, 2005, 7 (08) : 758 - U19
[14] E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages
Christensen, Devin E.
Brzovic, Peter S.
Klevit, Rachel E.
[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (10) : 941 - 948
[15] Allosteric Activation of E2-RING Finger-Mediated Ubiquitylation by a Structurally Defined Specific E2-Binding Region of gp78
Das, Ranabir
Mariano, Jennifer
Tsai, Yien Che
Kalathur, Ravi C.
Kostova, Zlatka
Li, Jess
Tarasov, Sergey G.
McFeeters, Robert L.
Altieri, Amanda S.
Ji, Xinhua
Byrd, R. Andrew
Weissman, Allan M.
[J]. MOLECULAR CELL, 2009, 34 (06) : 674 - 685
[16] Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
Deng, L
Wang, C
Spencer, E
Yang, LY
Braun, A
You, JX
Slaughter, C
Pickart, C
Chen, ZJ
[J]. CELL, 2000, 103 (02) : 351 - 361
[17] RING Domain E3 Ubiquitin Ligases
Deshaies, Raymond J.
Joazeiro, Claudio A. P.
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2009, 78 : 399 - 434
[18] Ubiquitin-binding domains - from structures to functions
Dikic, Ivan
Wakatsuki, Soichi
Walters, Kylie J.
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (10) : 659 - 671
[19] Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches
Dominguez, C
Bonvin, AMJJ
Winkler, GS
van Schaik, FMA
Timmers, HTM
Boelens, R
[J]. STRUCTURE, 2004, 12 (04) : 633 - 644
[20] Structural insights into NEDD8 activation of Cullin-RING ligases: Conformational control of conjugation
Duda, David M.
Borg, Laura A.
Scott, Daniel C.
Hunt, Harold W.
Hammel, Michal
Schulman, Brenda A.
[J]. CELL, 2008, 134 (06) : 995 - 1006

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