Selective Amine Cross-Coupling Using Iridium-Catalyzed "Borrowing Hydrogen" Methodology

被引：151

作者：

Saidi, Ourida ^{[1
]}

Blacker, A. John ^{[2
,3
]}

Farah, Mohamed M. ^{[2
,3
]}

Marsden, Stephen P. ^{[2
,3
]}

Williams, Jonathan M. J. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England

[3] Univ Leeds, Inst Proc Res & Dev, Leeds LS2 9JT, W Yorkshire, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 40期

基金：

英国工程与自然科学研究理事会;

关键词：

alkylation; amination; hydrogen; homogeneous catalysis; iridium; ASTERISK-IR COMPLEX; DYNAMIC KINETIC RESOLUTION; N-ALKYLATION; TERTIARY-AMINES; EFFICIENT CATALYSTS; ALIPHATIC-AMINES; SECONDARY-AMINES; AROMATIC-AMINES; ARYL AMINES; ALCOHOLS;

D O I：

10.1002/anie.200904028

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Something borrowed: Amine cross-coupling reactions are catalyzed using [{Cp*IrI2}2] (Cp*=C 5Me5) in the absence of a base. A range of anilines were converted into their N-isopropyl derivatives, and the same process was also effective for alkylation of benzylamines and other aliphatic primary amines. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7375 / 7378

页数：4

共 52 条

[1] Ruthenium-complex-catalyzed N-(cyclo)alkylation of aromatic amines with diols.: Selective synthesis of N-(ω-hydroxyalkyl)anilines of type PhNH(CH2)nOH and of some bioactive arylpiperazines [J].