Organoids-on-a-chip

被引：633

作者：

Park, Sunghee Estelle ^{[1
]}

Georgescu, Andrei ^{[1
]}

Huh, Dongeun ^{[1
,2
,3
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Inst Regenerat Med, Philadelphia, PA 19104 USA

[3] Univ Penn, NSF Sci & Technol Ctr Engn Mech, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2019年 / 364卷 / 6444期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

MODELING DEVELOPMENT; GENERATION; DISEASE; NETWORKS; BIOLOGY; TISSUES;

D O I：

10.1126/science.aaw7894

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent studies have demonstrated an array of stem cell-derived, self-organizing miniature organs, termed organoids, that replicate the key structural and functional characteristics of their in vivo counterparts. As organoid technology opens up new frontiers of research in biomedicine, there is an emerging need for innovative engineering approaches for the production, control, and analysis of organoids and their microenvironment. In this Review, we explore organ-on-a-chip technology as a platform to fulfill this need and examine how this technology may be leveraged to address major technical challenges in organoid research. We also discuss emerging opportunities and future obstacles for the development and application of organoid-on-a-chip technology.

引用

页码：960 / 965

页数：6

共 63 条

[1] Advances in Organoid Technology: Hans Clevers, Madeline Lancaster, and Takanori Takebe [J].

不详 .

CELL STEM CELL, 2017, 20 (06) :759-762

[2] Hepatic organoids for microfluidic drug screening [J].

Au, Sam H. ;

Chamberlain, M. Dean ;

Mahesh, Shruthi ;

Sefton, Michael V. ;

Wheeler, Aaron R. .

LAB ON A CHIP, 2014, 14 (17) :3290-3299

[3] Engineered In Vitro Disease Models [J].

Benam, Kambez H. ;

Dauth, Stephanie ;

Hassell, Bryan ;

Herland, Anna ;

Jain, Abhishek ;

Jang, Kyung-Jin ;

Karalis, Katia ;

Kim, Hyun Jung ;

MacQueen, Luke ;

Mahmoodian, Roza ;

Musah, Samira ;

Torisawa, Yu-suke ;

van der Meer, Andries D. ;

Villenave, Remi ;

Yadid, Moran ;

Parker, Kevin K. ;

Ingber, Donald E. .

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 10, 2015, 10 :195-262

[4] Millifluidic culture improves human midbrain organoid vitality and differentiation [J].

Berger, Emanuel ;

Magliaro, Chiara ;

Paczia, Nicole ;

Monzel, Anna S. ;

Antony, Paul ;

Linster, Carole L. ;

Bolognin, Silvia ;

Ahluwalia, Arti ;

Schwamborn, Jens C. .

LAB ON A CHIP, 2018, 18 (20) :3172-3183

[5] Engineers are from PDMS-land, Biologists are from Polystyrenia [J].

Berthier, Erwin ;

Young, Edmond W. K. ;

Beebe, David .

LAB ON A CHIP, 2012, 12 (07) :1224-1237

[6] Microfluidic organs-on-chips [J].

Bhatia, Sangeeta N. ;

Ingber, Donald E. .

NATURE BIOTECHNOLOGY, 2014, 32 (08) :760-772

[7] On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics [J].

Chen, Michelle B. ;

Whisler, Jordan A. ;

Froese, Julia ;

Yu, Cathy ;

Shin, Yoojin ;

Kamm, Roger D. .

NATURE PROTOCOLS, 2017, 12 (05) :865-880

[8] Clarifying intact 3D tissues on a microfluidic chip for high-throughput structural analysis [J].

Chen, Yih Yang ;

Silva, Pamuditha N. ;

Syed, Abdullah Muhammed ;

Sindhwani, Shrey ;

Rocheleau, Jonathan V. ;

Chan, Warren C. W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (52) :14915-14920

[9] Organ-on-a-chip for assessing environmental toxicants [J].

Cho, Soohee ;

Yoon, Jeong-Yeol .

CURRENT OPINION IN BIOTECHNOLOGY, 2017, 45 :34-42

[10] Modeling Development and Disease with Organoids [J].

Clevers, Hans .

CELL, 2016, 165 (07) :1586-1597

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