Core decompression combined with implantation of β-tricalcium phosphate modified by a BMSC affinity cyclic peptide for the treatment of early osteonecrosis of the femoral head

被引：1
作者：
Wang, Guozong [1 ]
Xin, Hua [2 ]
Tian, Guanghao [3 ]
Sheng, Kuisheng [4 ]
Zhang, Nianping [5 ]
Sun, Shui [6 ]
机构：
[1] Peoples Hosp Rizhao, Dept Joint Surg, Rizhao 276800, Shandong, Peoples R China
[2] Peoples Hosp Rizhao, Dept Neurol, Rizhao 276800, Shandong, Peoples R China
[3] Lixia Peoples Hosp, Dept Internal Med, Jinan 250014, Shandong, Peoples R China
[4] Rizhao City Tradit Chinese Med Hosp, Dept Orthoped, Rizhao 276800, Shandong, Peoples R China
[5] Shandong Univ Tradit Chinese Med, Teaching & Res Sect Surg, Clin Coll 1, Jinan 250355, Shandong, Peoples R China
[6] Shandong Univ, Dept Joint Surg, Shandong Prov Hosp, 324 Jingwuweiqi Rd, Jinan 250021, Shandong, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2021年 / 13卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Osteonecrosis of the femoral head; beta-tricalcium phosphate; affinity cyclic peptide; bone marrow mesen-chymal stem cell; core decompression; INDUCED AVASCULAR NECROSIS; CLINICAL-TRIAL; REPAIR;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Early intervention of osteonecrosis of the femoral head (ONFH) is very important. At present, the therapeutic effect on early ONFH is not completely satisfactory. D7 peptide has special affinity towards bone marrow mesenchymal stem cell (BMSC). Taking advantage of the adsorption/freeze-drying strategy, we constructed D7 cyclic peptide-modified beta-tricalcium phosphate (beta-TCP) scaffolds. The functional beta-TCP scaffolds can enhance adhesion, spreading and proliferation of BMSCs compared with unmodified beta-TCP scaffolds, which was comfired in cytological experiments. In rabbit model of early ONFH, functional beta-TCP scaffolds were stuffed into the cavities after core decompression (CD). Radiographic and histological examination confirmed that CD followed by filling of functional beta-TCP scaffolds can obviously improve the therapeutic effect of early ONFH. Our study provides a new option for curing early ONFH.
引用
收藏
页码：967 / 978
页数：12
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