Gastrostomy Tube Feeding in Extremely Low Birthweight Infants: Frequency, Associated Comorbidities, and Long-term Outcomes

被引：28

作者：

Warren, Mollie G. ^{[1
]}

Do, Barbara ^{[2
]}

Das, Abhik ^{[2
]}

Smith, P. Brian ^{[1
]}

Adams-Chapman, Ira ^{[3
]}

Jadcherla, Sudarshan ^{[4
]}

Jensen, Erik A. ^{[5
,6
]}

Goldstein, Ricki F. ^{[1
]}

Goldberg, Ronald N. ^{[1
]}

Cotten, C. Michael ^{[1
]}

Bell, Edward F. ^{[7
]}

Malcolm, William F. ^{[1
]}

Caplan, Michael S. ^{[8
]}

Laptook, Abbott R. ^{[9
,10
]}

Keszler, Martin ^{[9
,10
]}

Vohr, Betty R. ^{[9
,10
]}

Hensman, Angelita M. ^{[9
,10
]}

Alksninis, Barbara ^{[9
,10
]}

Basso, Kristin M. ^{[9
,10
]}

Burke, Robert ^{[9
,10
]}

Caskey, Melinda ^{[9
,10
]}

Johnson, Katharine ^{[9
,10
]}

Keszler, Mary Lenore ^{[9
,10
]}

Knoll, Andrea M. ^{[9
,10
]}

Leach, Theresa M. ^{[9
,10
]}

Little, Emilee ^{[9
,10
]}

McGowan, Elisabeth C. ^{[9
,10
]}

Vieira, Elisa ^{[9
,10
]}

Watson, Victoria E. ^{[9
,10
]}

Ventura, Suzy ^{[9
,10
]}

Walsh, Michele C. ^{[11
]}

Hibbs, Anna Maria ^{[11
]}

Wilson-Costello, Deanne E. ^{[11
]}

Newman, Nancy S. ^{[11
]}

Payne, Allison H. ^{[11
]}

Siner, Bonnie S. ^{[11
]}

Bhola, Monika ^{[11
]}

Yalcinkaya, Gulgun ^{[11
]}

Truog, William E. ^{[12
]}

Pallotto, Eugenia K. ^{[12
]}

Kilbride, Howard W. ^{[12
]}

Gauldin, Cheri ^{[12
]}

Holmes, Anne ^{[12
]}

Johnson, Kathy ^{[12
]}

Scott, Allison ^{[12
]}

Schibler, Kurt ^{[13
,14
]}

Donovan, Edward F. ^{[13
,14
]}

Grisby, Cathy ^{[13
,14
]}

Bridges, Kate ^{[13
,14
]}

Alexander, Barbara ^{[13
,14
]}

机构：

[1] Duke Univ, Dept Pediat, DUMC Box 2739, Durham, NC 27710 USA

[2] RTI Int, Social Stat & Environm Sci Unit, Rockville, MD USA

[3] Emory Univ, Sch Med, Dept Pediat, Childrens Healthcare Atlanta, Atlanta, GA USA

[4] Nationwide Childrens Hosp, Dept Pediat, Columbus, OH USA

[5] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[6] Univ Penn, Philadelphia, PA 19104 USA

[7] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA

[8] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

[9] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA

[10] Women & Infants Hosp Rhode Isl, Providence, RI 02908 USA

[11] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Cleveland, OH 44106 USA

[12] Univ Missouri, Sch Med, Childrens Mercy Hosp, Kansas City, MO 64108 USA

[13] Univ Hosp, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH USA

[14] Good Samaritan Hosp, Cincinnati, OH USA

[15] Duke Univ, Sch Med, Univ North Carolina, Univ Hosp, Durham, NC USA

[16] Duke Reg Hosp, Durham, NC USA

[17] Emory Univ, Childrens Healthcare Atlanta, Grady Mem Hosp, Atlanta, GA 30322 USA

[18] Emory Univ, Hosp Midtown, Atlanta, GA 30322 USA

[19] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Rockville, MD USA

[20] Indiana Univ, Riley Hosp Children, Methodist Hosp, Univ Hosp, Indianapolis, IN 46204 USA

[21] Wishard Hlth Serv, Indianapolis, IN USA

[22] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Childrens Mem Hermann Hosp, Houston, TX 77030 USA

[23] Lyndon Baines Johnson Gen Hosp, Harris Cty Hosp Dist, Houston, TX USA

[24] Nationwide Childrens Hosp, Columbus, OH USA

[25] Ohio State Univ, Med Ctr, Columbus, OH 43210 USA

[26] RTI Int, Rockville, MD USA

[27] Stanford Univ, Dominican Hosp, El Camino Hosp, Mountain View, CA USA

[28] Lucile Packard Childrens Hosp, Mountain View, CA USA

[29] Tufts Med Ctr, Floating Hosp Children, Boston, MA 02111 USA

[30] Univ Alabama Birmingham Hlth Syst, Birmingham, AL USA

[31] Childrens Hosp Alabama, Birmingham, AL USA

[32] Univ Calif Los Angeles, Mattel Childrens Hosp, Santa Mon Hosp, Los Robles Hosp & Med Ctr, Los Angeles, CA USA

[33] Olive View Med Ctr, Los Angeles, CA USA

[34] Univ Calif San Diego, Med Ctr, 225 Dickinson St, San Diego, CA 92103 USA

[35] Sharp Mary Birch Hosp Women & Newborns, San Diego, CA USA

[36] Univ Iowa, Cedar Rapids, IA USA

[37] Mercy Med Ctr, Cedar Rapids, IA USA

[38] Univ Miami, Holtz Childrens Hosp, Miami, FL USA

[39] Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA

[40] Univ Penn, Hosp Univ Penn, Penn Hosp, Philadelphia, PA 19104 USA

[41] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[42] Univ Rochester, Med Ctr, Golisano Childrens Hosp, Rochester, NY 14642 USA

[43] Univ Buffalo, Womens & Childrens Hosp Buffalo, Buffalo, NY USA

[44] Univ Texas Southwestern Med Ctr Dallas, Parkland Hlth & Hosp Syst, Dallas, TX 75390 USA

[45] Childrens Med Ctr Dallas, Dallas, TX USA

[46] Univ Utah, Med Ctr, Intermt Med Ctr, LDS Hosp, Salt Lake City, UT USA

[47] Primary Childrens Med Ctr, Salt Lake City, UT 84103 USA

[48] Wake Forest Univ, Baptist Med Ctr, Forsyth Med Ctr, Winston Salem, NC 27101 USA

[49] Brenner Childrens Hosp, Winston Salem, NC USA

[50] Wayne State Univ, Hutzel Womens Hosp, Detroit, MI USA

来源：

JOURNAL OF PEDIATRICS | 2019年 / 214卷

关键词：

PRETERM INFANTS; NECROTIZING ENTEROCOLITIS; EARLY DISCHARGE; IMPACT; HOME; COORDINATION; RESPIRATION; CHILDREN;

D O I：

10.1016/j.jpeds.2019.06.066

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective To assess the frequency of gastrostomy tube (GT) placement in extremely low birth weight (ELBW) infants, associated comorbidities, and long-term outcomes. Study design Analysis of ELBW infants from 25 centers enrolled in the National Institute of Child Health and Human Development Neonatal Research Network's Generic Database and Follow-up Registry from 2006 to 2012. Frequency of GT placement before 18-22 months, demographic and medical factors associated with GT placement, and associated long-term outcomes at 18-22 months of corrected age were described. Associations between GT placement and neonatal morbidities and long-term outcomes were assessed with logistic regression after adjustment for center and common co-variables. Results Of the 4549 ELBW infants included in these analyses, 333 (7.3%) underwent GT placement; 76% had the GT placed postdischarge. Of infants with GTs, 11 % had birth weights small for gestational age, 77% had bronchopulmonary dysplasia, and 29% severe intraventricular hemorrhage or periventricular leukomalacia. At follow-up, 56% of infants with a GT had weight <10th percentile, 61 % had neurodevelopmental impairment (NDI), and 55% had chronic breathing problems. After adjustment, small for gestational age, bronchopulmonary dysplasia, intraventricular hemorrhage/periventricular leukomalacia, poor growth, and NDI were associated with GT placement. Thirty-two percent of infants with GTs placed were taking full oral feeds at follow-up. Conclusions GT placement is common in ELBW infants, particularly among those with severe neonatal morbidities. GT placement in this population was associated with poor growth, NDI, and chronic respiratory and feeding problems at follow-up. The frequency of GT placement postneonatal discharge indicates the need for close nutritional follow-up of ELBW infants.

引用

页码：41 / +

页数：11

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