Poly(β-cyclodextrin)-mediated polylactide-cholesterol stereocomplex micelles for controlled drug delivery

被引：71

作者：

Feng, Xiang-ru ^{[1
]}

Ding, Jian-xun ^{[1
]}

Gref, Ruxandra ^{[2
]}

Chen, Xue-si ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

[2] Univ Paris Saclay, Univ Paris Sud, CNRS, Inst Mol Sci, F-91400 Orsay, France

来源：

CHINESE JOURNAL OF POLYMER SCIENCE | 2017年 / 35卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Polylactide; Stereocomplex micelle; Poly(beta-cyclodextrin); Host-guest interaction; Controlled drug delivery; BLOCK-COPOLYMER MICELLES; EFFICACY; PRODRUGS; RELEASE;

D O I：

10.1007/s10118-017-1932-7

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A series of host-guest interaction-adjusted polylactide stereocomplex micelles was prepared via the self-assembly of 4-armed poly(ethylene glycol)-block-poly(L-lactide/D-lactide)-cholesterol (4-armed PEG-b-PLLA/PDLA-CHOL) and poly(beta-cyclodextrin) (PCD) with the molar ratios of CHOL/beta-CD at 1:0.5, 1:1, and 1:2 in an aqueous environment. The hydrodynamic diameters of the micelles ranged from 84.1 nm to 107 nm depending on the molar ratio of CHOL/beta-CD. It was shown that the micelle with the largest proportion of PCD possessed excellent abilities in drug release, cell internalization as well as proliferation inhibitory effect toward human A549 lung cancer cells. The results demonstrated that the stereocomplex and host-guest interactions-mediated PLA micelles exhibited great potential in sustained drug delivery.

引用

页码：693 / 699

页数：7

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