Targeting the PD-1/PD-L1 axis in multiple myeloma: a dream or a reality?

被引：88

作者：

Rosenblatt, Jacalyn ^{[1
]}

Avigan, David ^{[1
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, 330 Brookline Ave,KS 134, Boston, MA 02215 USA

来源：

BLOOD | 2017年 / 129卷 / 03期

关键词：

IMMUNE CHECKPOINT BLOCKADE; NATURAL-KILLER-CELL; CD8; T-CELLS; ANTI-PD-1; ANTIBODY; PD-1; BLOCKADE; PLASMA-CELLS; BONE-MARROW; B7-H1; PD-L1; NIVOLUMAB; IMMUNOTHERAPY;

D O I：

10.1182/blood-2016-08-731885

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway is a negative regulator of immune activation that is upregulated in multiple myeloma and is a critical component of the immunosuppressive tumor microenvironment. Expression is increased in advanced disease and in the presence of bone marrow stromal cells. PD-1/PD-L1 blockade is associated with tumor regression in several malignancies, but single-agent activity is limited in myeloma patients. Combination therapy involving strategies to expand myeloma-specific T cells and T-cell activation via PD-1/PD-L1 blockade are currently being explored.

引用

页码：275 / 279

页数：5

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