Efficacy and tolerability of pregabalin in essential tremor: A randomized, double-blind, placebo-controlled, crossover trial

被引:33
作者
Ferrara, Joseph M.
Kenney, Christopher
Davidson, Anthony L.
Shinawi, Lina
Kissel, Abigail M.
Jankovic, Joseph [1 ]
机构
[1] Baylor Coll Med, Parkinsons Dis Ctr, Dept Neurol, Houston, TX 77030 USA
关键词
Essential tremor; Pregabalin; Fahn-Tolosa-Marin Tremor Rating Scale (TRS); Quality of Life in Essential Tremor Questionnaire (QUEST); QUALITY-OF-LIFE;
D O I
10.1016/j.jns.2009.06.044
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We performed a double-blind, crossover-design study to assess the tolerability and efficacy of pregabalin (PGB) in patients with essential tremor (ET). Twenty patients (11 women: mean age of 62.2 +/- 12.7 years, mean ET duration of 25.5 +/- 14.9 years) with ET were randomized for treatment with PGB (150-600 mg/day) or placebo, titrated over 6 weeks. Identical assessments of the Fahn-Tolosa-Marin Tremor Rating Scale (TRS) (primary endpoint), Clinical Global Impression of Change (CGI-C), Quality of Life in Essential Tremor Questionnaire (QUEST), Hamilton Anxiety Scale (HAM-A), and a sleep hygiene questionnaire (HD-16) were made at the baseline, at the end of treatment periods for both drug and placebo, and following the 2-week washout period preceding crossover. We found no improvement in any of the TRS measures and a statistically significant worsening of QUEST scores while patients were taking PGB. Adverse events were similar in frequency to previously published studies of PGB, the most common being drowsiness and dizziness. (c) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:195 / 197
页数:3
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