Control of homeostasis of CD8+ memory T cells by opposing cytokines

被引：706
作者：
Ku, CC
Murakami, M
Sakamato, A
Kappler, J
Marrack, P
机构：
[1] Univ Colorado, Hlth Sci Ctr, Natl Jewish Med Ctr, Howard Hughes Med Inst,Dept Med, Denver, CO 80206 USA
[2] Univ Colorado, Hlth Sci Ctr, Dept Immunol, Denver, CO 80206 USA
[3] Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Biol, Denver, CO 80206 USA
[4] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80206 USA
[5] Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80206 USA
来源：
SCIENCE | 2000年 / 288卷 / 5466期
关键词：
D O I：
10.1126/science.288.5466.675
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Memory T cells maintain their numbers for long periods after antigen exposure, Here we show that CD8(+) T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2), Therefore, the numbers of CD8(+) memory T cells in animals are controlled by a balance between IL-15 and IL-2.
引用
收藏
页码：675 / 678
页数：4
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