RecQ helicases: at the heart of genetic stability

被引：46

作者：

Cobb, JA ^{[1
]}

Bjergbaek, L ^{[1
]}

Gasser, SM ^{[1
]}

机构：

[1] Univ Geneva, Dept Mol Biol, CH-1211 Geneva, Switzerland

来源：

FEBS LETTERS | 2002年 / 529卷 / 01期

关键词：

Sgs1p; checkpoints; DNA replication; DNA polymerase stability; RecQ helicases;

D O I：

10.1016/S0014-5793(02)03269-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The checkpoint-mediated control of DNA replication is essential for maintaining the stability of the genome and preventing cancer in humans. The RecQ family of helicases has been shown to be important for the maintenance of genomic integrity in organisms ranging from bacteria to man. We propose that the RecQ homologue, Sgs1p, has an important function in the S-phase checkpoint response of budding yeast, where it may be both a 'sensor' for damage during replication and a 'resolvase' for structures that arise at paused forks. RecQ helicases may serve a unique function that integrates checkpoint proteins with the recombination and replication fork machinery. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：43 / 48

页数：6

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